Lithium in breast milk and nursing infants: Clinical implications

Adele C. Viguera, D. Jeffrey Newport, James Ritchie, Zachary Stowe, Theodore Whitfield, Juliana Mogielnicki, Ross J. Baldessarini, Amanda Zurick, Lee S. Cohen

Research output: Contribution to journalArticle

106 Scopus citations

Abstract

Objective: Current practice guidelines discourage use of lithium during breast-feeding, despite limited data. This study aimed to quantify lithium exposure in nursing infants. Method: In 10 mother-infant pairs, the authors obtained assays of lithium in maternal serum, breast milk, and infant serum and indices of infant renal and thyroid function. Results: Maternal serum, breast milk, and infant serum daily trough concentrations of lithium averaged 0.76, 0.35, and 0.16 meq/liter, respectively, each lithium level lower than the preceding level by approximately one-half. No serious adverse events were observed, and elevations of thyroid-stimulating hormone, blood urea nitrogen, and creatinine were few, minor, and transient. Conclusions: Serum lithium levels in nursing infants were low and well tolerated. No significant adverse clinical or behavioral effects in the infants were noted. These findings encourage reassessment of recommendations against lithium during breastfeeding and underscore the importance of close clinical monitoring of nursing infants.

Original languageEnglish (US)
Pages (from-to)342-345
Number of pages4
JournalAmerican Journal of Psychiatry
Volume164
Issue number2
DOIs
StatePublished - Feb 2007

ASJC Scopus subject areas

  • Psychiatry and Mental health

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    Viguera, A. C., Newport, D. J., Ritchie, J., Stowe, Z., Whitfield, T., Mogielnicki, J., Baldessarini, R. J., Zurick, A., & Cohen, L. S. (2007). Lithium in breast milk and nursing infants: Clinical implications. American Journal of Psychiatry, 164(2), 342-345. https://doi.org/10.1176/ajp.2007.164.2.342