Lithium and GSK-3: One inhibitor, two inhibitory actions, multiple outcomes

Research output: Contribution to journalArticle

367 Citations (Scopus)

Abstract

The intrigue of lithium, the simplest drug in the modern pharmacopoeia, extends from its complex actions in cells to its therapeutic effects as a mood stabilizer. New surprises from studies of glycogen synthase kinase 3 (GSK-3) show that lithium reduces GSK-3 activity in two ways, both directly and by increasing the inhibitory phosphorylation of GSK-3. These dual effects can act in concert to magnify the influence of lithium on crucial GSK-3-regulated functions (gene expression, cell structure and survival).

Original languageEnglish
Pages (from-to)441-443
Number of pages3
JournalTrends in Pharmacological Sciences
Volume24
Issue number9
DOIs
StatePublished - Sep 1 2003
Externally publishedYes

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Glycogen Synthase Kinase 3
Lithium
Phosphorylation
Pharmacopoeias
Therapeutic Uses
Gene expression
Cell Survival
Gene Expression
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Lithium and GSK-3 : One inhibitor, two inhibitory actions, multiple outcomes. / Jope, Richard S.

In: Trends in Pharmacological Sciences, Vol. 24, No. 9, 01.09.2003, p. 441-443.

Research output: Contribution to journalArticle

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