Lithium and GSK-3: One inhibitor, two inhibitory actions, multiple outcomes

Research output: Contribution to journalShort survey

376 Scopus citations

Abstract

The intrigue of lithium, the simplest drug in the modern pharmacopoeia, extends from its complex actions in cells to its therapeutic effects as a mood stabilizer. New surprises from studies of glycogen synthase kinase 3 (GSK-3) show that lithium reduces GSK-3 activity in two ways, both directly and by increasing the inhibitory phosphorylation of GSK-3. These dual effects can act in concert to magnify the influence of lithium on crucial GSK-3-regulated functions (gene expression, cell structure and survival).

Original languageEnglish (US)
Pages (from-to)441-443
Number of pages3
JournalTrends in Pharmacological Sciences
Volume24
Issue number9
DOIs
StatePublished - Sep 1 2003
Externally publishedYes

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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