Abstract
The intrigue of lithium, the simplest drug in the modern pharmacopoeia, extends from its complex actions in cells to its therapeutic effects as a mood stabilizer. New surprises from studies of glycogen synthase kinase 3 (GSK-3) show that lithium reduces GSK-3 activity in two ways, both directly and by increasing the inhibitory phosphorylation of GSK-3. These dual effects can act in concert to magnify the influence of lithium on crucial GSK-3-regulated functions (gene expression, cell structure and survival).
| Original language | English |
|---|---|
| Pages (from-to) | 441-443 |
| Number of pages | 3 |
| Journal | Trends in Pharmacological Sciences |
| Volume | 24 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 1 2003 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pharmacology
- Toxicology
Cite this
Lithium and GSK-3 : One inhibitor, two inhibitory actions, multiple outcomes. / Jope, Richard S.
In: Trends in Pharmacological Sciences, Vol. 24, No. 9, 01.09.2003, p. 441-443.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lithium and GSK-3
T2 - One inhibitor, two inhibitory actions, multiple outcomes
AU - Jope, Richard S
PY - 2003/9/1
Y1 - 2003/9/1
N2 - The intrigue of lithium, the simplest drug in the modern pharmacopoeia, extends from its complex actions in cells to its therapeutic effects as a mood stabilizer. New surprises from studies of glycogen synthase kinase 3 (GSK-3) show that lithium reduces GSK-3 activity in two ways, both directly and by increasing the inhibitory phosphorylation of GSK-3. These dual effects can act in concert to magnify the influence of lithium on crucial GSK-3-regulated functions (gene expression, cell structure and survival).
AB - The intrigue of lithium, the simplest drug in the modern pharmacopoeia, extends from its complex actions in cells to its therapeutic effects as a mood stabilizer. New surprises from studies of glycogen synthase kinase 3 (GSK-3) show that lithium reduces GSK-3 activity in two ways, both directly and by increasing the inhibitory phosphorylation of GSK-3. These dual effects can act in concert to magnify the influence of lithium on crucial GSK-3-regulated functions (gene expression, cell structure and survival).
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UR - http://www.scopus.com/inward/citedby.url?scp=0042379932&partnerID=8YFLogxK
U2 - 10.1016/S0165-6147(03)00206-2
DO - 10.1016/S0165-6147(03)00206-2
M3 - Article
C2 - 12967765
AN - SCOPUS:0042379932
VL - 24
SP - 441
EP - 443
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
SN - 0165-6147
IS - 9
ER -