Lisch-Knotchen. Marker der Neurofibromatose I und immunhistochemische Hinweise fur eine neuroektodermale Differenzierung

Translated title of the contribution: Lisch nodules. A marker for Neurofibromatosis I and immunohistochemical evidence for neuroectodermal differentiation

Andreas Lukacs, Anna K. Junk, Fritz H. Stefani, Anselm Kampik, Carl Georg Schirren, Gerd Plewig

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Iris nodules in neurofibromatosis I have become an important tool in the differential diagnosis of phakomatoses. The clinical appearance and importance of these nodules first recognized by Karl Lisch in Munich in 1937. The diagnosis and differential diagnosis of Lisch nodules are illustrated. The importance of iris nodules in genetic counselling of patients and their relatives is discussed, with emphasis on monosymptomatic cases. Histologically Lisch nodules are formed by aggregations of oval to round cells that form dome-shaped papules on the anterior layer of the iris. Immunohistochemically these cells are characterized by positive staining with antibodies against vimentin and S-100 protein. This proves their ectodermal differentiation. Thus Lisch nodules can be seen as a direct manifestation of neuroectodermal disturbances in neurofibromatosis I.

Translated title of the contributionLisch nodules. A marker for Neurofibromatosis I and immunohistochemical evidence for neuroectodermal differentiation
Original languageGerman
Pages (from-to)38-41
Number of pages4
JournalHautarzt
Volume48
Issue number1
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

Keywords

  • histology
  • immunohistochemistry
  • Lisch nodules
  • neurofibromatosis I

ASJC Scopus subject areas

  • Dermatology

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