Lipotoxicity and decreased islet graft survival

Cristiane B. Leitão, Karina Bernetti, Thipaporn Tharavanij, Pablo Cure, Vincenzo Lauriola, Per Olof Berggren, Camillo Ricordi, Rodolfo Alejandro

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

OBJECTIVE - To evaluate if baseline serum lipids are associated with islet graft survival in type 1 diabetes islet transplant (ITx) recipients. RESEARCH DESIGN AND METHODS - Baseline fasting lipid profile was collected from 44 ITx recipients. Comparisons were performed between subjects below and above the median values of each lipid fraction. Differences in outcomes were compared by Kaplan-Meier curves and Cox regression analysis. RESULTS - Subjects with baseline fasting plasma triglycerides and VLDL cholesterol above the median had shorter islet graft survival (triglycerides: 39.7± 6.1 vs. 61.3 ± 6.6 months, P = 0.029, and VLDL: 41.5 ± 5.7 vs. 62.8 ± 7.3 months, P = 0.032). Total, LDL, and HDL cholesterol did not influence islet function. Triglycerides (odds ratio 2.97 [95% CI 1.03- 8.52], P = 0.044) maintained its association with graft failure after adjustments for confounders. CONCLUSIONS - Higher baseline triglycerides are associated with earlier decline in islet graft function. Prospective clinical trials should address whether it is directly caused by lipotoxicity and if strategies focusing on lowering serum lipids may prolong islet graft survival.

Original languageEnglish
Pages (from-to)658-660
Number of pages3
JournalDiabetes Care
Volume33
Issue number3
DOIs
StatePublished - Mar 1 2010

Fingerprint

Graft Survival
Lipids
Triglycerides
Fasting
Transplants
VLDL Cholesterol
Serum
Type 1 Diabetes Mellitus
LDL Cholesterol
HDL Cholesterol
Research Design
Odds Ratio
Regression Analysis
Clinical Trials

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this

Leitão, C. B., Bernetti, K., Tharavanij, T., Cure, P., Lauriola, V., Berggren, P. O., ... Alejandro, R. (2010). Lipotoxicity and decreased islet graft survival. Diabetes Care, 33(3), 658-660. https://doi.org/10.2337/dc09-1387

Lipotoxicity and decreased islet graft survival. / Leitão, Cristiane B.; Bernetti, Karina; Tharavanij, Thipaporn; Cure, Pablo; Lauriola, Vincenzo; Berggren, Per Olof; Ricordi, Camillo; Alejandro, Rodolfo.

In: Diabetes Care, Vol. 33, No. 3, 01.03.2010, p. 658-660.

Research output: Contribution to journalArticle

Leitão, CB, Bernetti, K, Tharavanij, T, Cure, P, Lauriola, V, Berggren, PO, Ricordi, C & Alejandro, R 2010, 'Lipotoxicity and decreased islet graft survival', Diabetes Care, vol. 33, no. 3, pp. 658-660. https://doi.org/10.2337/dc09-1387
Leitão CB, Bernetti K, Tharavanij T, Cure P, Lauriola V, Berggren PO et al. Lipotoxicity and decreased islet graft survival. Diabetes Care. 2010 Mar 1;33(3):658-660. https://doi.org/10.2337/dc09-1387
Leitão, Cristiane B. ; Bernetti, Karina ; Tharavanij, Thipaporn ; Cure, Pablo ; Lauriola, Vincenzo ; Berggren, Per Olof ; Ricordi, Camillo ; Alejandro, Rodolfo. / Lipotoxicity and decreased islet graft survival. In: Diabetes Care. 2010 ; Vol. 33, No. 3. pp. 658-660.
@article{fe79256f97804e919fc80a9d9111277f,
title = "Lipotoxicity and decreased islet graft survival",
abstract = "OBJECTIVE - To evaluate if baseline serum lipids are associated with islet graft survival in type 1 diabetes islet transplant (ITx) recipients. RESEARCH DESIGN AND METHODS - Baseline fasting lipid profile was collected from 44 ITx recipients. Comparisons were performed between subjects below and above the median values of each lipid fraction. Differences in outcomes were compared by Kaplan-Meier curves and Cox regression analysis. RESULTS - Subjects with baseline fasting plasma triglycerides and VLDL cholesterol above the median had shorter islet graft survival (triglycerides: 39.7± 6.1 vs. 61.3 ± 6.6 months, P = 0.029, and VLDL: 41.5 ± 5.7 vs. 62.8 ± 7.3 months, P = 0.032). Total, LDL, and HDL cholesterol did not influence islet function. Triglycerides (odds ratio 2.97 [95{\%} CI 1.03- 8.52], P = 0.044) maintained its association with graft failure after adjustments for confounders. CONCLUSIONS - Higher baseline triglycerides are associated with earlier decline in islet graft function. Prospective clinical trials should address whether it is directly caused by lipotoxicity and if strategies focusing on lowering serum lipids may prolong islet graft survival.",
author = "Leit{\~a}o, {Cristiane B.} and Karina Bernetti and Thipaporn Tharavanij and Pablo Cure and Vincenzo Lauriola and Berggren, {Per Olof} and Camillo Ricordi and Rodolfo Alejandro",
year = "2010",
month = "3",
day = "1",
doi = "10.2337/dc09-1387",
language = "English",
volume = "33",
pages = "658--660",
journal = "Diabetes Care",
issn = "1935-5548",
publisher = "American Diabetes Association Inc.",
number = "3",

}

TY - JOUR

T1 - Lipotoxicity and decreased islet graft survival

AU - Leitão, Cristiane B.

AU - Bernetti, Karina

AU - Tharavanij, Thipaporn

AU - Cure, Pablo

AU - Lauriola, Vincenzo

AU - Berggren, Per Olof

AU - Ricordi, Camillo

AU - Alejandro, Rodolfo

PY - 2010/3/1

Y1 - 2010/3/1

N2 - OBJECTIVE - To evaluate if baseline serum lipids are associated with islet graft survival in type 1 diabetes islet transplant (ITx) recipients. RESEARCH DESIGN AND METHODS - Baseline fasting lipid profile was collected from 44 ITx recipients. Comparisons were performed between subjects below and above the median values of each lipid fraction. Differences in outcomes were compared by Kaplan-Meier curves and Cox regression analysis. RESULTS - Subjects with baseline fasting plasma triglycerides and VLDL cholesterol above the median had shorter islet graft survival (triglycerides: 39.7± 6.1 vs. 61.3 ± 6.6 months, P = 0.029, and VLDL: 41.5 ± 5.7 vs. 62.8 ± 7.3 months, P = 0.032). Total, LDL, and HDL cholesterol did not influence islet function. Triglycerides (odds ratio 2.97 [95% CI 1.03- 8.52], P = 0.044) maintained its association with graft failure after adjustments for confounders. CONCLUSIONS - Higher baseline triglycerides are associated with earlier decline in islet graft function. Prospective clinical trials should address whether it is directly caused by lipotoxicity and if strategies focusing on lowering serum lipids may prolong islet graft survival.

AB - OBJECTIVE - To evaluate if baseline serum lipids are associated with islet graft survival in type 1 diabetes islet transplant (ITx) recipients. RESEARCH DESIGN AND METHODS - Baseline fasting lipid profile was collected from 44 ITx recipients. Comparisons were performed between subjects below and above the median values of each lipid fraction. Differences in outcomes were compared by Kaplan-Meier curves and Cox regression analysis. RESULTS - Subjects with baseline fasting plasma triglycerides and VLDL cholesterol above the median had shorter islet graft survival (triglycerides: 39.7± 6.1 vs. 61.3 ± 6.6 months, P = 0.029, and VLDL: 41.5 ± 5.7 vs. 62.8 ± 7.3 months, P = 0.032). Total, LDL, and HDL cholesterol did not influence islet function. Triglycerides (odds ratio 2.97 [95% CI 1.03- 8.52], P = 0.044) maintained its association with graft failure after adjustments for confounders. CONCLUSIONS - Higher baseline triglycerides are associated with earlier decline in islet graft function. Prospective clinical trials should address whether it is directly caused by lipotoxicity and if strategies focusing on lowering serum lipids may prolong islet graft survival.

UR - http://www.scopus.com/inward/record.url?scp=77649267543&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77649267543&partnerID=8YFLogxK

U2 - 10.2337/dc09-1387

DO - 10.2337/dc09-1387

M3 - Article

C2 - 20009097

AN - SCOPUS:77649267543

VL - 33

SP - 658

EP - 660

JO - Diabetes Care

JF - Diabetes Care

SN - 1935-5548

IS - 3

ER -