Lipotoxicity and decreased islet graft survival

Cristiane B. Leitão, Karina Bernetti, Thipaporn Tharavanij, Pablo Cure, Vincenzo Lauriola, Per Olof Berggren, Camillo Ricordi, Rodolfo Alejandro

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

OBJECTIVE - To evaluate if baseline serum lipids are associated with islet graft survival in type 1 diabetes islet transplant (ITx) recipients. RESEARCH DESIGN AND METHODS - Baseline fasting lipid profile was collected from 44 ITx recipients. Comparisons were performed between subjects below and above the median values of each lipid fraction. Differences in outcomes were compared by Kaplan-Meier curves and Cox regression analysis. RESULTS - Subjects with baseline fasting plasma triglycerides and VLDL cholesterol above the median had shorter islet graft survival (triglycerides: 39.7± 6.1 vs. 61.3 ± 6.6 months, P = 0.029, and VLDL: 41.5 ± 5.7 vs. 62.8 ± 7.3 months, P = 0.032). Total, LDL, and HDL cholesterol did not influence islet function. Triglycerides (odds ratio 2.97 [95% CI 1.03- 8.52], P = 0.044) maintained its association with graft failure after adjustments for confounders. CONCLUSIONS - Higher baseline triglycerides are associated with earlier decline in islet graft function. Prospective clinical trials should address whether it is directly caused by lipotoxicity and if strategies focusing on lowering serum lipids may prolong islet graft survival.

Original languageEnglish (US)
Pages (from-to)658-660
Number of pages3
JournalDiabetes care
Volume33
Issue number3
DOIs
StatePublished - Mar 2010

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

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    Leitão, C. B., Bernetti, K., Tharavanij, T., Cure, P., Lauriola, V., Berggren, P. O., Ricordi, C., & Alejandro, R. (2010). Lipotoxicity and decreased islet graft survival. Diabetes care, 33(3), 658-660. https://doi.org/10.2337/dc09-1387