Lipoprotein composition in patients with type 1 diabetes mellitus: Impact of lipases and adipokines

Objective: High cardiovascular mortality in patients with type 1 diabetes (T1DM) is widely recognized. Paradoxically, these patients have been shown to have elevated HDL-C and reduced apoB-containing lipoproteins. The purpose of this investigation was to further characterize the lipoprotein composition in T1DM and to assess the role that lipases and adipokines may play in these differences. Methods: T1DM patients (89) attending the Diabetes Clinic at the University of Miami and 42 healthy controls were recruited. Clinical characteristics, lipoprotein composition (by ultracentrifugation and HPLC), leptin, and adiponectin were measured in the full cohort, while a subgroup had LPL and hepatic lipase measured. Results: Subjects were predominately Caucasian and Hispanic. HgbA1c's were above goal while their mean duration of diabetes was >. 20. years. LPL was 2-fold elevated in diabetic women versus controls (+. 107%(p = 0.001)) with no difference in men. Hepatic lipase was reduced 50% (p.