Lipomatous hemangiopericytoma: A histologic, ultrastructural and immunohistochemical study of a unique variant of hemangiopericytoma

G. P. Nielsen, G. R. Dickersin, J. M. Provenzal, A. E. Rosenberg

Research output: Contribution to journalArticlepeer-review

92 Scopus citations


We report three cases of a unique, previously undescribed soft tissue tumor composed of mature adipocytes and hemangiopericytomatous areas, for which we propose the term lipomatous hemangiopericytoma. The tumors occurred in adults and were located in the sinonasal area, the soft tissue of the shoulder, and the retroperitoneum. The tumors ranged in size from 4 to 10 cm in greatest diameter and grossly were solid and ranged from tan to yellow. Histologically, they were composed of a variable admixture of benign lipomatous and hemangiopericytomatous components. Immunohistochemically, they stained with antibodies to vimentin and not to alpha-smooth-muscle actin, muscle-specific actin, desmin, S-100 protein, glial fibrillary acidic protein, epithelial membrane antigen, or keratin. Ultrastructurally, the cells constituting the hemangiopericytomatous areas had the features of pericytes, and no lipoblasts or transitional forms between lipocytes and pericytes were found. The histologic differential diagnosis of this neoplasm includes spindle-cell lipoma, angiolipoma, liposarcomas, tumors showing smooth muscle and adipocytic differentiation, and hemangiopericytoma infiltrating fat. Because of the small number of cases and the limited follow-up, we cannot be certain of their biologic behavior, although we expect that they are benign. Lipomatous hemangiopericytoma represents a distinctive pathologic entity that should be recognized and studied further.

Original languageEnglish (US)
Pages (from-to)748-756
Number of pages9
JournalAmerican Journal of Surgical Pathology
Issue number7
StatePublished - Jan 1 1995
Externally publishedYes


  • Hemangiopericytoma
  • Lipoma
  • Soft tissue

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine


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