Lipidomics dataset of sonication-induced traumatic optic neuropathy in mice

Ronaldo Nuesi, Ryan A. Gallo, Galina Dvoriantchikova, Daniel Pelaez, Sanjoy K. Bhattacharya

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Traumatic optic neuropathy (TON) is the loss of vision secondary to trauma. Approximately two weeks after traumatic damage, diffuse retinal ganglion cell loss and axon degeneration of the optic nerve are exhibited [1]. Here we present the changes that occur in the optic nerve lipidome of two-month-old C57BL/6J mice following sonication-induced TON (SI-TON), which closely models the indirect clinical mechanism in TON. Optic nerves were harvested at three time points following injury: 1-day, 7-days, and 14-days for comparison with the control group (uninjured optic nerves from 2-month-old mice). The optic nerves were subjected to mass spectrometry and bioinformatic analysis using LipidSearch 4.1.3 and Metaboanalyst 4.0. This data pertains to the lipidome at each time point following indirect trauma to the optic nerve. The data presented here will augment investigation into the neurodegenerative process. The data is available at Metabolomics Workbench [http://www.metabolomicsworkbench.org (Project ID: PR000859)].

Original languageEnglish (US)
Article number105147
JournalData in Brief
Volume29
DOIs
StatePublished - Apr 2020

Keywords

  • Lipid profile
  • Liquid chromatography-mass spectrometry
  • Metabolomics
  • Neurodegeneration
  • Optic nerve injury
  • Traumatic optic neuropathy

ASJC Scopus subject areas

  • General

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