Lipid-rich pleural mesothelioma in a dog

Arlen Avakian, Joseph Alroy, Elizabeth Rozanski, John Keating, Andrew Rosenberg

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


An 11-year-old, neutered, male Golden Retriever cross dog was euthanized following a history of recurrent pericardial effusions. At necropsy, blood-tinged pericardial and intrathoracic effusions were seen along with numerous firm to hard plaque-like masses that studded the epicardial, pericardial, mediastinal, and costal pleural surfaces. Within the right thorax, the lesions coalesced into a large mass that occupied most of the cavity. Histologically, the masses were composed of solid sheets and papillary aggregates of medium-sized polygonal cells that contained abundant vacuolated to clear cytoplasm. Some of the cytoplasmic vacuoles stained positive with oil red O. The stroma contained metaplastic trabeculae of woven and lamellar bone. Immunohistochemically, the neoplastic cells expressed vimentin, pancytokeratin, and S-100 protein, Transmission electron microscopy corroborated the presence of intracytoplasmic vacuoles and demonstrated prominent intercellular junctional complexes and apically located microvilli, These findings are consistent with a lipid-rich variant of mesothelioma. To the authors' knowledge, this is the first report of a lipid-rich mesothelioma in a dog.

Original languageEnglish (US)
Pages (from-to)665-667
Number of pages3
JournalJournal of Veterinary Diagnostic Investigation
Issue number5
StatePublished - Sep 1 2008
Externally publishedYes


  • Lipid-rich
  • Mesothelioma
  • Pericardial

ASJC Scopus subject areas

  • veterinary(all)


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