TY - JOUR
T1 - Lipid mobilizing hormones of the hypothalamus and pituitary
AU - Kastin, A. J.
AU - Redding, T. W.
AU - Hall, R.
AU - Besser, G. M.
AU - Schally, A. V.
N1 - Funding Information:
Schildkraut and Kety \[22\] suggest that catecholamines, particularly norepinephrine, are implicated in emotional states and behavior. Recent developments in the biochemistry of aggression provide some evidence for the hypothesis that the emotional reactivity produced by brain damage may also involve catecholaminergic systems. Research by one of us (B.K.B.) has revealed correlations between brain catecholamine levels and dynamics, and different models of aggression: (1) shock-induced, con- This work was supported in part by a University of Connecticut Research Foundation Grant to B.K.B. and J.R.B. was supported by an NIMH Training Grant MH-11935-04 to the Department of Psychology. The authors wish to thank Dr. Uwe Koehn for his assistance in the statistical evaluation of these data and Dr. P. Rosenberg for editorial comments.
PY - 1975
Y1 - 1975
N2 - Lipid mobilizing substances (LMS) are present in the hypothalamus and pituitary of mammals and probably are involved in the central neural control of obesity. Most of these have direct lipolytic effects, like lipid mobilizing factor (LMF) and LH RH from the hypothalamus as well as lipoprotein (LPH), melanocyte stimulating hormone (MSH), corticotropin (ACTH), and growth hormone (GH) from the pituitary gland. Some of the substances, like GH release inhibiting hormone (GH RIH), affect lipolysis by secondary actions on pancreatic hormones such as insulin and glucagon. Other hypothalamic hormones, like GH releasing hormone (GH RH) may influence lipolysis secondarily through the pituitary hormones (e.g. GH) whose release they control. Regardless of how lipid mobilization is affected, investigations into the problem of obesity should take these LMS into consideration.
AB - Lipid mobilizing substances (LMS) are present in the hypothalamus and pituitary of mammals and probably are involved in the central neural control of obesity. Most of these have direct lipolytic effects, like lipid mobilizing factor (LMF) and LH RH from the hypothalamus as well as lipoprotein (LPH), melanocyte stimulating hormone (MSH), corticotropin (ACTH), and growth hormone (GH) from the pituitary gland. Some of the substances, like GH release inhibiting hormone (GH RIH), affect lipolysis by secondary actions on pancreatic hormones such as insulin and glucagon. Other hypothalamic hormones, like GH releasing hormone (GH RH) may influence lipolysis secondarily through the pituitary hormones (e.g. GH) whose release they control. Regardless of how lipid mobilization is affected, investigations into the problem of obesity should take these LMS into consideration.
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U2 - 10.1016/0091-3057(75)90090-8
DO - 10.1016/0091-3057(75)90090-8
M3 - Article
C2 - 179103
AN - SCOPUS:0016810980
VL - 3
SP - 121
EP - 126
JO - Scientific Computing and Instrumentation
JF - Scientific Computing and Instrumentation
SN - 1078-8956
IS - 1 Sup.
ER -