Lipid mediators of insulin signaling in diabetic kidney disease

Alla Mitrofanova, Marie Anne Sosa, Alessia Fornoni

Research output: Contribution to journalArticle

Abstract

Diabetic kidney disease (DKD) affects ∼40% of patients with diabetes and is associated with high mortality rates. Among different cellular targets in DKD, podocytes, highly specialized epithelial cells of the glomerular filtration barrier, are injured in the early stages of DKD. Both clinical and experimental data support the role of preserved insulin signaling as a major contributor to podocyte function and survival. However, little is known about the key modulators of podocyte insulin signaling. This review summarizes the novel knowledge that intracellular lipids such as cholesterol and sphingolipids are major determinants of podocyte insulin signaling. In particular, the implications of these lipids on DKD development, progression, and treatment will be addressed.

Original languageEnglish (US)
Pages (from-to)F1241-F1252
JournalAmerican journal of physiology. Renal physiology
Volume317
Issue number5
DOIs
StatePublished - Nov 1 2019

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Keywords

  • ceramide-1-phosphate
  • cholesterol
  • diabetic kidney disease
  • insulin signaling
  • podocyte
  • sphingolipids
  • sphingosine-1-phosphate

ASJC Scopus subject areas

  • Physiology
  • Urology

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