Lipid-lowering therapy in patients with peripheral arterial disease: Are guidelines being met?

Daniel G. Federman, Dana C. Ranani, Robert S. Kirsner, Dawn M. Bravata

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


OBJECTIVES: To determine the proportion of patients with lower extremity peripheral arterial disease (PAD) who reach recommended low-density lipoprotein cholesterol (LDL-C) levels (<100 mg/dl) and to identify the patient characteristics that are independently associated with attaining the LDL-C goal (<100 mg/dL). PATIENTS AND METHODS: Eligible patients were identified from a roster of patients who had undergone testing at a nonvascular laboratory between September 1, 2001, and January 31, 2002, and were found to have evidence of PAD, defined as an ankle-brachial index of 0.9 or less. We thoroughly reviewed patients' electronic medical records. Backward elimination multivariate logistic regression modeling was used to identify factors associated with reaching the goal LDL-C level. RESULTS: Among 143 patients with PAD, 105 (73%) met the goal LDL-C level. Lipid-lowering therapy was prescribed for 109 (76%). Lower diastolic blood pressure and lower weight were independently associated with an LDL-C level of less than 100 mg/dL. CONCLUSION: We found higher rates of lipid-lowering therapy in patients with PAD than reported previously. Patients with diabetes mellitus or coronary artery disease were not more likely to meet the goal LDL-C level than those without these comorbidities. Clinical practice may be catching up to clinical guidelines.

Original languageEnglish (US)
Pages (from-to)494-498
Number of pages5
JournalMayo Clinic Proceedings
Issue number4
StatePublished - Apr 2005
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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