Lipid levels are associated with a regulatory polymorphism of the monoamine oxidase-A gene promoter (MAOA-uVNTR)

Beverly H. Brummett, Stephen H. Boyle, Ilene C. Siegler, Stephan L Zuchner, Allison Ashley-Koch, Redford B. Williams

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: The monoamine oxidase-A (MAOA) gene plays a vital role in the metabolism of neurotransmitters, e.g, serotonin, norepinephrine, and dopamine. A polymorphism in the promoter region (MAOAuVNTR) affects transcriptional efficiency. Allelic variation in MAOA-uVNTR has been associated with body mass index (BMI). We extended previous work by examining relations among this polymorphism and serum lipid levels. Material/Methods: The sample consisted of 74 males enrolled in a study of caregivers for relatives with dementia. Regression models, adjusted for age, race, group status (caregiver/control), and cholesterol lowering medication (yes/no), were used to examine associations between high verses low MAOA-uVNTR activity alleles and total cholesterol, HDL, LDL, VLDL, LDL/HDL ratio, triglycerides, and BMI. Results: Higher total cholesterol (p<0.03), LDL/HDL ratio (p<0.01), triglycerides (p<0.02), and VLDL (p<0.02) were associated with low activity MAOA-uVNTR alleles. HDL and LDL were modestly related to MAOA-uVNTR activity, however, they did not reach the conventional significance level (p<0.07 and p<0.10, respectively). BMI (p<0.74) was unrelated to MAOA-uVNTR transcription. Conclusions: The present findings suggest that MAOA-uVNTR may influence lipid levels and individuals with less active alleles are at increased health risk.

Original languageEnglish
JournalMedical Science Monitor
Volume14
Issue number2
StatePublished - Feb 1 2008

Fingerprint

Monoamine Oxidase
Lipids
Genes
Body Mass Index
Alleles
Caregivers
Triglycerides
Cholesterol
Genetic Promoter Regions
LDL Cholesterol
HDL Cholesterol
Neurotransmitter Agents
Dementia
Dopamine
Serotonin
Norepinephrine
Age Groups
Health
Serum
oxidized low density lipoprotein

Keywords

  • Allelic variation
  • Genetics
  • Lipoprotien
  • Stress

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Brummett, B. H., Boyle, S. H., Siegler, I. C., Zuchner, S. L., Ashley-Koch, A., & Williams, R. B. (2008). Lipid levels are associated with a regulatory polymorphism of the monoamine oxidase-A gene promoter (MAOA-uVNTR). Medical Science Monitor, 14(2).

Lipid levels are associated with a regulatory polymorphism of the monoamine oxidase-A gene promoter (MAOA-uVNTR). / Brummett, Beverly H.; Boyle, Stephen H.; Siegler, Ilene C.; Zuchner, Stephan L; Ashley-Koch, Allison; Williams, Redford B.

In: Medical Science Monitor, Vol. 14, No. 2, 01.02.2008.

Research output: Contribution to journalArticle

Brummett, Beverly H. ; Boyle, Stephen H. ; Siegler, Ilene C. ; Zuchner, Stephan L ; Ashley-Koch, Allison ; Williams, Redford B. / Lipid levels are associated with a regulatory polymorphism of the monoamine oxidase-A gene promoter (MAOA-uVNTR). In: Medical Science Monitor. 2008 ; Vol. 14, No. 2.
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