Lipid in Renal Carcinoma: Queen Bee to Target?

Sze Kiat Tan, Scott M. Welford

Research output: Contribution to journalShort surveypeer-review

1 Scopus citations

Abstract

Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer subtype, characterized by a lipid storage phenotype. We found that carnitine palmitoyltransferase 1A (CPT1A), the rate-limiting enzyme of mitochondrial fatty acid (FA) transport, is repressed by hypoxia-inducible factors (HIFs), reducing FA oxidation (FAO). Altering lipid metabolism may be a new therapeutic avenue in ccRCC.

Original languageEnglish (US)
Pages (from-to)448-450
Number of pages3
JournalTrends in Cancer
Volume6
Issue number6
DOIs
StatePublished - Jun 2020

Keywords

  • CPT1A
  • HIF
  • ccRCC
  • clear cell renal cell carcinoma
  • hypoxia
  • lipid metabolism

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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