Abstract
Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer subtype, characterized by a lipid storage phenotype. We found that carnitine palmitoyltransferase 1A (CPT1A), the rate-limiting enzyme of mitochondrial fatty acid (FA) transport, is repressed by hypoxia-inducible factors (HIFs), reducing FA oxidation (FAO). Altering lipid metabolism may be a new therapeutic avenue in ccRCC.
Original language | English (US) |
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Pages (from-to) | 448-450 |
Number of pages | 3 |
Journal | Trends in Cancer |
Volume | 6 |
Issue number | 6 |
DOIs | |
State | Published - Jun 2020 |
Keywords
- ccRCC
- clear cell renal cell carcinoma
- CPT1A
- HIF
- hypoxia
- lipid metabolism
ASJC Scopus subject areas
- Oncology
- Cancer Research