Lipid in Renal Carcinoma: Queen Bee to Target?

Sze Kiat Tan; Scott M. Welford

doi:10.1016/j.trecan.2020.02.017

Lipid in Renal Carcinoma: Queen Bee to Target?

Sze Kiat Tan, Scott M. Welford

Radiation Oncology

Research output: Contribution to journal › Short survey › peer-review

6 Scopus citations

Abstract

Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer subtype, characterized by a lipid storage phenotype. We found that carnitine palmitoyltransferase 1A (CPT1A), the rate-limiting enzyme of mitochondrial fatty acid (FA) transport, is repressed by hypoxia-inducible factors (HIFs), reducing FA oxidation (FAO). Altering lipid metabolism may be a new therapeutic avenue in ccRCC.

Original language	English (US)
Pages (from-to)	448-450
Number of pages	3
Journal	Trends in Cancer
Volume	6
Issue number	6
DOIs	https://doi.org/10.1016/j.trecan.2020.02.017
State	Published - Jun 2020

Keywords

CPT1A
HIF
ccRCC
clear cell renal cell carcinoma
hypoxia
lipid metabolism

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.trecan.2020.02.017

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@article{be07e6ab6234482d98a3f19b523cd9dc,

title = "Lipid in Renal Carcinoma: Queen Bee to Target?",

abstract = "Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer subtype, characterized by a lipid storage phenotype. We found that carnitine palmitoyltransferase 1A (CPT1A), the rate-limiting enzyme of mitochondrial fatty acid (FA) transport, is repressed by hypoxia-inducible factors (HIFs), reducing FA oxidation (FAO). Altering lipid metabolism may be a new therapeutic avenue in ccRCC.",

keywords = "CPT1A, HIF, ccRCC, clear cell renal cell carcinoma, hypoxia, lipid metabolism",

author = "Tan, {Sze Kiat} and Welford, {Scott M.}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = jun,

doi = "10.1016/j.trecan.2020.02.017",

language = "English (US)",

volume = "6",

pages = "448--450",

journal = "Trends in Cancer",

issn = "2405-8033",

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number = "6",

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TY - JOUR

T1 - Lipid in Renal Carcinoma

T2 - Queen Bee to Target?

AU - Tan, Sze Kiat

AU - Welford, Scott M.

PY - 2020/6

Y1 - 2020/6

N2 - Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer subtype, characterized by a lipid storage phenotype. We found that carnitine palmitoyltransferase 1A (CPT1A), the rate-limiting enzyme of mitochondrial fatty acid (FA) transport, is repressed by hypoxia-inducible factors (HIFs), reducing FA oxidation (FAO). Altering lipid metabolism may be a new therapeutic avenue in ccRCC.

AB - Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer subtype, characterized by a lipid storage phenotype. We found that carnitine palmitoyltransferase 1A (CPT1A), the rate-limiting enzyme of mitochondrial fatty acid (FA) transport, is repressed by hypoxia-inducible factors (HIFs), reducing FA oxidation (FAO). Altering lipid metabolism may be a new therapeutic avenue in ccRCC.

KW - CPT1A

KW - HIF

KW - ccRCC

KW - clear cell renal cell carcinoma

KW - hypoxia

KW - lipid metabolism

UR - http://www.scopus.com/inward/record.url?scp=85081694801&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85081694801&partnerID=8YFLogxK

U2 - 10.1016/j.trecan.2020.02.017

DO - 10.1016/j.trecan.2020.02.017

M3 - Short survey

C2 - 32459999

AN - SCOPUS:85081694801

VL - 6

SP - 448

EP - 450

JO - Trends in Cancer

JF - Trends in Cancer

SN - 2405-8033

IS - 6

ER -

Lipid in Renal Carcinoma: Queen Bee to Target?

Abstract

Keywords

ASJC Scopus subject areas

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