Lipid in Renal Carcinoma: Queen Bee to Target?

Sze Kiat Tan; Scott M. Welford

doi:10.1016/j.trecan.2020.02.017

Lipid in Renal Carcinoma: Queen Bee to Target?

Sze Kiat Tan, Scott M. Welford

Radiation Oncology

Research output: Contribution to journal › Short survey › peer-review

Abstract

Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer subtype, characterized by a lipid storage phenotype. We found that carnitine palmitoyltransferase 1A (CPT1A), the rate-limiting enzyme of mitochondrial fatty acid (FA) transport, is repressed by hypoxia-inducible factors (HIFs), reducing FA oxidation (FAO). Altering lipid metabolism may be a new therapeutic avenue in ccRCC.

Original language	English (US)
Pages (from-to)	448-450
Number of pages	3
Journal	Trends in Cancer
Volume	6
Issue number	6
DOIs	https://doi.org/10.1016/j.trecan.2020.02.017
State	Published - Jun 2020

Keywords

ccRCC
clear cell renal cell carcinoma
CPT1A
HIF
hypoxia
lipid metabolism

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Lipid in Renal Carcinoma: Queen Bee to Target?",

abstract = "Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer subtype, characterized by a lipid storage phenotype. We found that carnitine palmitoyltransferase 1A (CPT1A), the rate-limiting enzyme of mitochondrial fatty acid (FA) transport, is repressed by hypoxia-inducible factors (HIFs), reducing FA oxidation (FAO). Altering lipid metabolism may be a new therapeutic avenue in ccRCC.",

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AU - Welford, Scott M.

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N2 - Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer subtype, characterized by a lipid storage phenotype. We found that carnitine palmitoyltransferase 1A (CPT1A), the rate-limiting enzyme of mitochondrial fatty acid (FA) transport, is repressed by hypoxia-inducible factors (HIFs), reducing FA oxidation (FAO). Altering lipid metabolism may be a new therapeutic avenue in ccRCC.

AB - Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer subtype, characterized by a lipid storage phenotype. We found that carnitine palmitoyltransferase 1A (CPT1A), the rate-limiting enzyme of mitochondrial fatty acid (FA) transport, is repressed by hypoxia-inducible factors (HIFs), reducing FA oxidation (FAO). Altering lipid metabolism may be a new therapeutic avenue in ccRCC.

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KW - CPT1A

KW - HIF

KW - hypoxia

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