Lipid exudation following plaque radiotherapy for posterior uveal melanoma

Michael D. Mills, J. William Harbour

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

PURPOSE: To investigate factors associated with lipid exudation after plaque radiotherapy for uveal melanoma. DESIGN: Retrospective interventional case series. METHODS: Records of 139 consecutive uveal melanoma patients treated with I-125 plaque radiotherapy were reviewed. Lipid exudation was the major outcome measured. RESULTS: Lipid exudation was detected in 19 patients (13.7%). Mean time from plaque therapy to lipid exudation was 10 months (range, 3-23 months). Lipid exudation was associated with younger patient age (P = .0002), increased low-density lipoprotein (P = .004), decreased high-density lipoprotein (P = .026), increased tumor thickness (P = .024), and exudative retinal detachment (P = .016). Patients with lipid exudation had worse visual outcome (P < .0001) and increased neovascular glaucoma (P = .01). CONCLUSIONS: Lipid exudation after plaque radiotherapy for uveal melanoma is associated with poor ocular outcome. Factors associated with this lipid exudation are distinct from those associated with radiation retinopathy, and they may suggest interventions to combat this complication.

Original languageEnglish
JournalAmerican Journal of Ophthalmology
Volume141
Issue number3
DOIs
StatePublished - Mar 1 2006
Externally publishedYes

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Radiotherapy
Lipids
Neovascular Glaucoma
Uveal melanoma
Retinal Detachment
HDL Lipoproteins
LDL Lipoproteins
Radiation
Neoplasms

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Lipid exudation following plaque radiotherapy for posterior uveal melanoma. / Mills, Michael D.; William Harbour, J.

In: American Journal of Ophthalmology, Vol. 141, No. 3, 01.03.2006.

Research output: Contribution to journalArticle

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abstract = "PURPOSE: To investigate factors associated with lipid exudation after plaque radiotherapy for uveal melanoma. DESIGN: Retrospective interventional case series. METHODS: Records of 139 consecutive uveal melanoma patients treated with I-125 plaque radiotherapy were reviewed. Lipid exudation was the major outcome measured. RESULTS: Lipid exudation was detected in 19 patients (13.7{\%}). Mean time from plaque therapy to lipid exudation was 10 months (range, 3-23 months). Lipid exudation was associated with younger patient age (P = .0002), increased low-density lipoprotein (P = .004), decreased high-density lipoprotein (P = .026), increased tumor thickness (P = .024), and exudative retinal detachment (P = .016). Patients with lipid exudation had worse visual outcome (P < .0001) and increased neovascular glaucoma (P = .01). CONCLUSIONS: Lipid exudation after plaque radiotherapy for uveal melanoma is associated with poor ocular outcome. Factors associated with this lipid exudation are distinct from those associated with radiation retinopathy, and they may suggest interventions to combat this complication.",
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