Lipid disorders in type 1 and type 2 diabetes

R. B. Goldberg, D. Capuzzi

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

Atherosclerotic cardiovascular disease (CVD) is the most important cause of morbidity and mortality in diabetic subjects. It has been estimated that people with diabetes are subject to a twofold to fourfold excess risk for coronary heart disease (CHD) and stroke and up to an eightfold increased likelihood of peripheral vascular disease compared with nondiabetic individuals. The reasons for this heightened incidence of CVD are complex and not completely understood. Abnormalities in circulating lipids and lipoproteins are considered to be important risk factors for CVD because they occur with increased frequency in diabetic individuals. Although most studies have focused on CHD, sufficient evidence points to similar relationships existing between lipid disorders and atherosclerosis in other arterial beds. Because reversal of these abnormalities carries the potential for preventing or ameliorating CVD, their identification and management with that of other CVD risk factors deserve equal importance to the management of hyperglycemia and is frequently complementary to it.

Original languageEnglish (US)
Pages (from-to)147-172
Number of pages26
JournalClinics in Laboratory Medicine
Volume21
Issue number1
StatePublished - Apr 23 2001

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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