Atherosclerotic cardiovascular disease (CVD) is the most important cause of morbidity and mortality in diabetic subjects. It has been estimated that people with diabetes are subject to a twofold to fourfold excess risk for coronary heart disease (CHD) and stroke and up to an eightfold increased likelihood of peripheral vascular disease compared with nondiabetic individuals. The reasons for this heightened incidence of CVD are complex and not completely understood. Abnormalities in circulating lipids and lipoproteins are considered to be important risk factors for CVD because they occur with increased frequency in diabetic individuals. Although most studies have focused on CHD, sufficient evidence points to similar relationships existing between lipid disorders and atherosclerosis in other arterial beds. Because reversal of these abnormalities carries the potential for preventing or ameliorating CVD, their identification and management with that of other CVD risk factors deserve equal importance to the management of hyperglycemia and is frequently complementary to it.
|Original language||English (US)|
|Number of pages||26|
|Journal||Clinics in Laboratory Medicine|
|State||Published - Apr 23 2001|
ASJC Scopus subject areas
- Clinical Biochemistry
- Biochemistry, medical