Lipid deposition and metaflammation in diabetic kidney disease

Alla Mitrofanova, Antonio M. Fontanella, Sandra Merscher, Alessia Fornoni

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

A critical link between metabolic disorders and a form of low-grade systemic and chronic inflammation has been recently established and named ‘Metaflammation’. Metaflammation has been recognized as a key mediator of both microvascular and macrovascular complications of diabetes and as a significant contributor to the development of diabetic kidney disease (DKD). The goal of this review is to summarize the contribution of diabetes-induced inflammation and the related signaling pathways to diabetic complications, with a particular focus on how innate immunity and lipid metabolism influence each other.

Original languageEnglish (US)
Pages (from-to)60-72
Number of pages13
JournalCurrent Opinion in Pharmacology
Volume55
DOIs
StatePublished - Dec 2020

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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