Links between inflammation and thrombogenicity in atherosclerosis

Juan Viles Gonzalez, Valentin Fuster, Juan J. Badimon

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Plaque disruption and subsequent thrombus formation play a critical role in the clinical manifestations of atherothrombosis. Vulnerable lesions are characterized by the existence of core rich in lipid, macrophages and tissue factor (TF). Plaque disruption facilitates the interaction between flowing blood with the inner components (TF) of disrupted atherosclerotic lesions triggering the coagulation cascade. TF, thrombin, platelets, fibrin and inflammatory cells are involved in this process of acute thrombus formation. This pathologic process is significantly accelerated by several "cardiovascular risk factors" such as diabetes, smoking, dyslipemia, etc. We will review on the role of TF, plaque cell apoptosis and blood thrombogenicity acting as a thread of inflammatory and prothrombotic mediators. We will also review the role of activated platelets as source for pro-inflammatory cytokines and enunciation of thrombotic process. Overall, we will try to emphasize the most recent understanding of the concepts involved in the interaction between inflammation and coagulation within the setting of atherothrombotic disease.

Original languageEnglish
Pages (from-to)489-499
Number of pages11
JournalCurrent Molecular Medicine
Volume6
Issue number5
DOIs
StatePublished - Aug 1 2006
Externally publishedYes

Fingerprint

Thromboplastin
Atherosclerosis
Inflammation
Platelets
Coagulation
Thrombosis
Blood
Blood Platelets
Macrophages
Pathologic Processes
Medical problems
Fibrin
Thrombin
Blood Cells
Smoking
Apoptosis
Cytokines
Lipids

Keywords

  • Apoptosis
  • Atherosclerosis
  • Atherothrombosis
  • High-risk patient
  • High-risk plaque
  • Inflammation
  • Plaque
  • Platelet
  • Thrombin
  • Thrombosis
  • Tissue factor
  • Vulnerable blood
  • Vulnerable plaque

ASJC Scopus subject areas

  • Biochemistry

Cite this

Links between inflammation and thrombogenicity in atherosclerosis. / Viles Gonzalez, Juan; Fuster, Valentin; Badimon, Juan J.

In: Current Molecular Medicine, Vol. 6, No. 5, 01.08.2006, p. 489-499.

Research output: Contribution to journalArticle

Viles Gonzalez, Juan ; Fuster, Valentin ; Badimon, Juan J. / Links between inflammation and thrombogenicity in atherosclerosis. In: Current Molecular Medicine. 2006 ; Vol. 6, No. 5. pp. 489-499.
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