Links between critical proteins drive the controllability of protein interaction networks

Stefan Wuchty, Toni Boltz, Hande Küçük-McGinty

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Focusing on the interactomes of Homo sapiens, Saccharomyces cerevisiae, and Escherichia coli, we investigated interactions between controlling proteins. In particular, we determined critical, intermittent, and redundant proteins based on their tendency to participate in minimum dominating sets. Independently of the organisms considered, we found that interactions that involved critical nodes had the most prominent effects on the topology of their corresponding networks. Furthermore, we observed that phosphorylation and regulatory events were considerably enriched when the corresponding transcription factors and kinases were critical proteins, while such interactions were depleted when they were redundant proteins. Moreover, interactions involving critical proteins were enriched with essential genes, disease genes, and drug targets, suggesting that such characteristics may be key for the detection of novel drug targets as well as assess their efficacy.

Original languageEnglish (US)
Article number1700056
JournalProteomics
Volume17
Issue number10
DOIs
StatePublished - May 1 2017

Fingerprint

Protein Interaction Maps
Controllability
Proteins
Genes
Phosphorylation
Essential Genes
Pharmaceutical Preparations
Yeast
Escherichia coli
Saccharomyces cerevisiae
Transcription Factors
Phosphotransferases
Topology

Keywords

  • Critical proteins
  • Network control
  • Protein–protein interactions

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Links between critical proteins drive the controllability of protein interaction networks. / Wuchty, Stefan; Boltz, Toni; Küçük-McGinty, Hande.

In: Proteomics, Vol. 17, No. 10, 1700056, 01.05.2017.

Research output: Contribution to journalArticle

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