Linked Social-Communication Dimensions and Connectivity in Functional Brain Networks in Autism Spectrum Disorder

Jinming Xiao, Huafu Chen, Xiaolong Shan, Changchun He, Ya Li, Xiaonan Guo, Heng Chen, Wei Liao, Lucina Q. Uddin, Xujun Duan

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Much recent attention has been directed toward elucidating the structure of social interaction-communication dimensions and whether and how these symptom dimensions coalesce with each other in individuals with autism spectrum disorder (ASD). However, the underlying neurobiological basis of these symptom dimensions is unknown, especially the association of social interaction and communication dimensions with brain networks. Here, we proposed a method of whole-brain network-based regression to identify the functional networks linked to these symptom dimensions in a large sample of children with ASD. Connectome-based predictive modeling (CPM) was established to explore neurobiological evidence that supports the merging of communication and social interaction deficits into one symptom dimension (social/communication deficits). Results showed that the default mode network plays a core role in communication and social interaction dimensions. A primary sensory perceptual network mainly contributed to communication deficits, and high-level cognitive networks mainly contributed to social interaction deficits. CPM revealed that the functional networks associated with these symptom dimensions can predict the merged dimension of social/communication deficits. These findings delineate a link between brain functional networks and symptom dimensions for social interaction and communication and further provide neurobiological evidence supporting the merging of communication and social interaction deficits into one symptom dimension.

Original languageEnglish (US)
Pages (from-to)3899-3910
Number of pages12
JournalCerebral Cortex
Volume31
Issue number8
DOIs
StatePublished - Aug 1 2021
Externally publishedYes

Keywords

  • autism spectrum disorder
  • connectome-based predictive modeling
  • functional brain networks
  • network-based regression
  • social-communication dimensions

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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