Linkage studies of the esterase D and retinoblastoma genes to canine copper toxicosis: A model for Wilson disease

V. Yuzbasiyan-Gurkan, S. Wagnitz, Susan H Blanton, G. J. Brewer

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Canine copper toxicosis, an autosomal recessive disorder, is prevalent among certain dog breeds. It results in liver disease from copper accumulation and toxicity similar to the human autosomal recessive disorder, Wilson disease. The Wilson disease locus has been mapped to 13q and is closely linked to the esterase D and retinoblastoma genes. We developed informative polymorphic systems in the dog using the human cDNA clones of the esterase D and retinoblastoma loci as probes. We investigated the linkage relationship of these two loci to the copper toxicosis locus, and to each other in the dog. Our results indicate that none of the loci are closely linked in the dog. Linkage of copper toxicosis to the retinoblastoma locus can be excluded up to 13% recombination, and to esterase D up to 5% recombination. Furthermore, esterase D and retinoblastoma, tightly linked in the mouse and human genomes, are not found to be closely linked in the canine genome.

Original languageEnglish
Pages (from-to)86-90
Number of pages5
JournalGenomics
Volume15
Issue number1
DOIs
StatePublished - Jan 1 1993
Externally publishedYes

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Retinoblastoma Genes
Hepatolenticular Degeneration
Retinoblastoma
Canidae
Copper
Dogs
Genetic Recombination
Human Genome
Liver Diseases
Complementary DNA
Clone Cells
Genome
s-formylglutathione hydrolase

ASJC Scopus subject areas

  • Genetics

Cite this

Linkage studies of the esterase D and retinoblastoma genes to canine copper toxicosis : A model for Wilson disease. / Yuzbasiyan-Gurkan, V.; Wagnitz, S.; Blanton, Susan H; Brewer, G. J.

In: Genomics, Vol. 15, No. 1, 01.01.1993, p. 86-90.

Research output: Contribution to journalArticle

Yuzbasiyan-Gurkan, V. ; Wagnitz, S. ; Blanton, Susan H ; Brewer, G. J. / Linkage studies of the esterase D and retinoblastoma genes to canine copper toxicosis : A model for Wilson disease. In: Genomics. 1993 ; Vol. 15, No. 1. pp. 86-90.
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