Linkage Studies in Tuberous Sclerosis: Chromosome 9?, 11?, or Maybe 14!

R. S. KANDT, M. A. PERICAK‐VANCE, W. ‐Y HUNG, R. J.M. GARDNER, P. E. CROSSEN, M. D. NELLIST, M. C. SPEER, A. D. ROSES

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10 Scopus citations

Abstract

Published reports show linkage of tuberous sclerosis (TSC) to either chromosome 9 in some families or chromosome 11 in other families. We studied 243 individuals (82 with TSC) from 16 multigenerational TSC families. The diagnosis of TSC conformed to the criteria of Gomez. Penetrance was estimated at 0.90. DNA markers were analyzed using Southern blotting, probe hybridization, autoradiography, and genetic linkage analysis. Two-point lod scores for TSC were calculated for 43 genetic markers distributed over 11 chromosomes. Tests for homogeneity rejected the null hypothesis of homogeneity. Linkage to TSC was excluded (z ≤ 2, Θ ≥ 0.05) for 23 of these markers including 9q34 and 11q markers. One family gave z[Θ(max)] = 1.8, Θ(max) = 0.001 with ABO (on 9q34), and two other families attained lod scores greater than 1 for 9q34-region markers. The lod score for TSC versus chromosome 14 marker pAW101 (D14S1) was z[Θ(max)] = 1.98, Θ(max) = 0.15. A single large family has overall negative lod scores for markers localized to both chromosome 9 and chromosome 11. These data confirm genetic heterogeneity in TSC and suggest linkage of some families to 9q34. Furthermore, the data suggest that 14q may be an interesting area.

Original languageEnglish (US)
Pages (from-to)284-297
Number of pages14
JournalAnnals of the New York Academy of Sciences
Volume615
Issue number1
DOIs
StatePublished - Apr 1991
Externally publishedYes

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ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

KANDT, R. S., PERICAK‐VANCE, M. A., HUNG, W. Y., GARDNER, R. J. M., CROSSEN, P. E., NELLIST, M. D., SPEER, M. C., & ROSES, A. D. (1991). Linkage Studies in Tuberous Sclerosis: Chromosome 9?, 11?, or Maybe 14! Annals of the New York Academy of Sciences, 615(1), 284-297. https://doi.org/10.1111/j.1749-6632.1991.tb37770.x