Abstract
Charcot-Marie-Tooth disease (CMT), the most common inherited peripheral neuropathy, is a progressive sensorimotor neuropathy divided into types 1 and 2 based upon electrophysiologic and neuropathologic differences. The more common autosomal dominant form of CMT type 1 (hereditary motor and sensory neuropathy type I) is genetically heterogeneous, with genes located on chromosomes 1 (type 1B) or 17 (type IA). However, no locus for CMT type 2 is known. We have performed linkage studies on three large multigenerational CMT type 2 families using probes from chromosome 1 and chromosome 17, which span their respective linkage regions. Multipoint analysis of the chromosome 17 markers excluded linkage over an area of 45 cM-15 cM proximal and 30 cM distal to the region containing CMT type 1A. Multipoint analysis of the chromosome 1 markers exclude linkage 15 cM proximal and 20 cM distal to FC-gamma-RII in the region of CMT IB. These data indicate that CMT type 2 is genetically distinct from CMT type 1.
Original language | English (US) |
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Pages (from-to) | 597-601 |
Number of pages | 5 |
Journal | Neurology |
Volume | 42 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1992 |
Externally published | Yes |
ASJC Scopus subject areas
- Clinical Neurology