Linkage relationships of the gene for the β subunit of nerve growth factor (NGFB) with other chromosome 1 marker loci

J. K. Darby, J. R. Kidd, A. J. Pakstis, R. S. Sparkes, H. M. Cann, R. E. Ferrell, D. G. Gerhard, V. Riccardi, J. A. Egeland, E. M. Shooter

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Recent linkage maps of chromosome 1 (Hamerton et al, 1984; Wedd, 1984) place PGM1 and Fy at slightly over 50 cM apart, suggesting that the prior probability that NGFB would show linkage with either PGM1 or Fy is very high. Consequently, these results represent strong evidence that NGFB is closer on the linkage map to Fy than it is to PGM1, and, in conjunction with the somatic cell localization (Munke et al, 1984), confirms that it falls between them. Although the NGFB locus has been mapped cytologically to the chromosomal segment between PGM1 and AMY2 (Munke et al, 1984), NGFB not only shows no evidence of linkage with PGM1 but the data are sufficient to exclude linkage below 16% recombination. The recent linkage maps of chromosome 1 (Hamerton et al, 1984; Wedd, 1984) also show a relative difference in the 'distances' on the cytological and linkage maps for the region just proximal to PGM1. AMY1 and AMY2 have been mapped to 1p21, just proximal to PGM1 but show >30% recombination with PGM1. We find that NGFB shows a similar pattern. Although NGFB should show close linkage to the AMY1 and AMY2 loci, AMY1 showed insufficient isozyme variation in the families tested to measure linkage. NRAS has also been mapped to 1p22 (Munke et al, 1984); its linkage relationships are not yet known.

Original languageEnglish (US)
Pages (from-to)158-160
Number of pages3
JournalCytogenetics and cell genetics
Volume39
Issue number2
StatePublished - 1985

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

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