Linkage of a commoner form of recessive amyotrophic lateral sclerosis to chromosome 15q15-q22 markers

Afif Hentati, Karim Ouahchi, Margaret A Pericak-Vance, Deepak Nijhawan, Arsalan Ahmad, Yi Yang, Jackie Rimmler, Wu Yen Hung, Beate Schlotter, Akhtar Ahmed, Mongi Ben Hamida, Fayçal Hentati, Teepu Siddique

Research output: Contribution to journalArticle

152 Citations (Scopus)

Abstract

Autosomal recessive familial amyotrophic lateral sclerosis (RFALS) is a rare form of ALS that usually presents at an early age with slow progression of symptoms. RFALS is clinically and genetically heterogeneous and the locus of RFALS type 3 was mapped to 2q33 (ALS2) in a single family. We now report linkage of a more-common form of RFALS to chromosome 15q15q22 markers (ALS5) and show further genetic locus heterogeneity in RFALS. ALS5 is the locus for most families with RFALS and appears to be present in both North African and European populations.

Original languageEnglish
Pages (from-to)55-60
Number of pages6
JournalNeurogenetics
Volume2
Issue number1
DOIs
StatePublished - Dec 1 1998
Externally publishedYes

Fingerprint

Amyotrophic Lateral Sclerosis
Chromosomes
Genetic Loci
Genetic Heterogeneity
Genetic Markers
Amyotrophic lateral sclerosis 1
Population

Keywords

  • Chromosome 15q15-q22 markers
  • Recessive amyotrophic lateral sclerosis

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuroscience(all)

Cite this

Linkage of a commoner form of recessive amyotrophic lateral sclerosis to chromosome 15q15-q22 markers. / Hentati, Afif; Ouahchi, Karim; Pericak-Vance, Margaret A; Nijhawan, Deepak; Ahmad, Arsalan; Yang, Yi; Rimmler, Jackie; Hung, Wu Yen; Schlotter, Beate; Ahmed, Akhtar; Ben Hamida, Mongi; Hentati, Fayçal; Siddique, Teepu.

In: Neurogenetics, Vol. 2, No. 1, 01.12.1998, p. 55-60.

Research output: Contribution to journalArticle

Hentati, A, Ouahchi, K, Pericak-Vance, MA, Nijhawan, D, Ahmad, A, Yang, Y, Rimmler, J, Hung, WY, Schlotter, B, Ahmed, A, Ben Hamida, M, Hentati, F & Siddique, T 1998, 'Linkage of a commoner form of recessive amyotrophic lateral sclerosis to chromosome 15q15-q22 markers', Neurogenetics, vol. 2, no. 1, pp. 55-60. https://doi.org/10.1007/s100480050052
Hentati, Afif ; Ouahchi, Karim ; Pericak-Vance, Margaret A ; Nijhawan, Deepak ; Ahmad, Arsalan ; Yang, Yi ; Rimmler, Jackie ; Hung, Wu Yen ; Schlotter, Beate ; Ahmed, Akhtar ; Ben Hamida, Mongi ; Hentati, Fayçal ; Siddique, Teepu. / Linkage of a commoner form of recessive amyotrophic lateral sclerosis to chromosome 15q15-q22 markers. In: Neurogenetics. 1998 ; Vol. 2, No. 1. pp. 55-60.
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