Linkage between axonal ensheathment and basal lamina production by Schwann cells.

R. P. Bunge, Mary B Bunge, C. F. Eldridge

Research output: Contribution to journalArticle

224 Citations (Scopus)

Abstract

The availability of several methods for the preparation of SCs free of other cell types has allowed recent experimentation providing new insights into the capacity of SCs to synthesize, release, and organize extracellular matrix materials, particularly those of the basal lamina. When these SC populations are combined in tissue culture with pure populations of neurons capable of directing SC function (without fibroblasts), new aspects of interrelationships between these cell types have come to light. In this brief chapter we review the results from this experimental approach during the last decade, and suggest the implications these observations have for interpreting known differences in SC functional expression in various body regions as well as for understanding certain disease processes. Of particular note is the discovery of an apparently essential linkage between the function of the SCs in organizing and relating to basal lamina and their ability to ensheathe and myelinate axons. It now appears that SC functional expression requires an alliance not only with the nerve fiber but also with the ECM through the production and organization of a basal lamina.

Original languageEnglish
Pages (from-to)305-328
Number of pages24
JournalAnnual Review of Neuroscience
Volume9
StatePublished - Jan 1 1986
Externally publishedYes

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Schwann Cells
Basement Membrane
Body Regions
Nerve Fibers
Population
Extracellular Matrix
Axons
Fibroblasts
Neurons

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Linkage between axonal ensheathment and basal lamina production by Schwann cells. / Bunge, R. P.; Bunge, Mary B; Eldridge, C. F.

In: Annual Review of Neuroscience, Vol. 9, 01.01.1986, p. 305-328.

Research output: Contribution to journalArticle

Bunge, R. P. ; Bunge, Mary B ; Eldridge, C. F. / Linkage between axonal ensheathment and basal lamina production by Schwann cells. In: Annual Review of Neuroscience. 1986 ; Vol. 9. pp. 305-328.
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