Linkage and association analysis of chromosome 19q13 in multiple sclerosis

Margaret A Pericak-Vance, Jacqueline B. Rimmler, Eden R Martin, Jonathan L. Haines, Melissa E. Garcia, Jorge R. Oksenberg, Lisa F. Barcellos, Robin Lincoln, Donald E. Goodkin, Stephen L. Hauser

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Multiple sclerosis (MS) is an autoimmune neurological disorder with a complex etiology. Sibling risk, twin, and adoption studies have demonstrated that genes play a vital role in susceptibility to MS. Numerous association and linkage studies have implicated the major histocompatibility complex (MHC) as one component of the genetic etiology, but additional loci remain to be identified. Genomic screens have suggested over 50 regions that might harbor these genes, but there has been little agreement between studies. The one region suggested by all four screens resides within chromosome 19q13. Allelic associations with several markers in this region have also been described. This region has now been examined in detail in an expanded dataset of MS families from the United States. Genetic linkage and association were tested with multiple markers in this region using both parametric and non-parametric analyses. Additional support for an MS susceptibility locus was observed, primarily in families with the MS-associated HLA-DR2 allele. While consistent, this effect appears to be modest with a maximum λS=1.47, probably representing no more than 10% of the overall genetic effect in MS.

Original languageEnglish
Pages (from-to)195-201
Number of pages7
JournalNeurogenetics
Volume3
Issue number4
DOIs
StatePublished - Dec 1 2001
Externally publishedYes

    Fingerprint

Keywords

  • Chromosome 19
  • Genetic linkage
  • Multiple sclerosis

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuroscience(all)

Cite this

Pericak-Vance, M. A., Rimmler, J. B., Martin, E. R., Haines, J. L., Garcia, M. E., Oksenberg, J. R., Barcellos, L. F., Lincoln, R., Goodkin, D. E., & Hauser, S. L. (2001). Linkage and association analysis of chromosome 19q13 in multiple sclerosis. Neurogenetics, 3(4), 195-201. https://doi.org/10.1007/s100480100119