Linkage analysis of peripheral neurofibromatosis to DNA markers on chromosome 8

S. R. Diehl; M. Boehnke; F. S. Collins; R. P. Erickson; I. J. Karolyi; L. M. Ploughman; M. A. Pericak-Vance; A. S. Aylsworth; A. D. Roses

doi:10.1136/jmg.24.9.532

Linkage analysis of peripheral neurofibromatosis to DNA markers on chromosome 8

S. R. Diehl, M. Boehnke, F. S. Collins, R. P. Erickson, I. J. Karolyi, L. M. Ploughman, M. A. Pericak-Vance, A. S. Aylsworth, A. D. Roses

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Linkage relationships of the gene for peripheral neurofibromatosis (NF) were assessed in a large American Caucasian pedigree using two DNA markers located on chromosome 8. Linkage to the thyroglobulin locus, located at 8q24, was excluded (lod < - 2.0) to 21 cM. Data obtained for the tissue plasminogen activator locus, located at 8p12, excluded linkage to 4 cM. These results exclude between 20 to 30% of chromosome 8 as a possible map location for the NF gene in this family. Comparison of the two DNA markers excluded their linkage to 0.5 cM.

Original language	English (US)
Pages (from-to)	532-534
Number of pages	3
Journal	Journal of medical genetics
Volume	24
Issue number	9
DOIs	https://doi.org/10.1136/jmg.24.9.532
State	Published - 1987
Externally published	Yes

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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title = "Linkage analysis of peripheral neurofibromatosis to DNA markers on chromosome 8",

abstract = "Linkage relationships of the gene for peripheral neurofibromatosis (NF) were assessed in a large American Caucasian pedigree using two DNA markers located on chromosome 8. Linkage to the thyroglobulin locus, located at 8q24, was excluded (lod < - 2.0) to 21 cM. Data obtained for the tissue plasminogen activator locus, located at 8p12, excluded linkage to 4 cM. These results exclude between 20 to 30% of chromosome 8 as a possible map location for the NF gene in this family. Comparison of the two DNA markers excluded their linkage to 0.5 cM.",

author = "Diehl, {S. R.} and M. Boehnke and Collins, {F. S.} and Erickson, {R. P.} and Karolyi, {I. J.} and Ploughman, {L. M.} and Pericak-Vance, {M. A.} and Aylsworth, {A. S.} and Roses, {A. D.}",

year = "1987",

doi = "10.1136/jmg.24.9.532",

language = "English (US)",

volume = "24",

pages = "532--534",

journal = "Journal of Medical Genetics",

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T1 - Linkage analysis of peripheral neurofibromatosis to DNA markers on chromosome 8

AU - Diehl, S. R.

AU - Boehnke, M.

AU - Collins, F. S.

AU - Erickson, R. P.

AU - Karolyi, I. J.

AU - Ploughman, L. M.

AU - Pericak-Vance, M. A.

AU - Aylsworth, A. S.

AU - Roses, A. D.

PY - 1987

Y1 - 1987

N2 - Linkage relationships of the gene for peripheral neurofibromatosis (NF) were assessed in a large American Caucasian pedigree using two DNA markers located on chromosome 8. Linkage to the thyroglobulin locus, located at 8q24, was excluded (lod < - 2.0) to 21 cM. Data obtained for the tissue plasminogen activator locus, located at 8p12, excluded linkage to 4 cM. These results exclude between 20 to 30% of chromosome 8 as a possible map location for the NF gene in this family. Comparison of the two DNA markers excluded their linkage to 0.5 cM.

AB - Linkage relationships of the gene for peripheral neurofibromatosis (NF) were assessed in a large American Caucasian pedigree using two DNA markers located on chromosome 8. Linkage to the thyroglobulin locus, located at 8q24, was excluded (lod < - 2.0) to 21 cM. Data obtained for the tissue plasminogen activator locus, located at 8p12, excluded linkage to 4 cM. These results exclude between 20 to 30% of chromosome 8 as a possible map location for the NF gene in this family. Comparison of the two DNA markers excluded their linkage to 0.5 cM.

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