Linkage analysis of peripheral neurofibromatosis to DNA markers on chromosome 8

S. R. Diehl, M. Boehnke, F. S. Collins, R. P. Erickson, I. J. Karolyi, L. M. Ploughman, M. A. Pericak-Vance, A. S. Aylsworth, A. D. Roses

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Linkage relationships of the gene for peripheral neurofibromatosis (NF) were assessed in a large American Caucasian pedigree using two DNA markers located on chromosome 8. Linkage to the thyroglobulin locus, located at 8q24, was excluded (lod < - 2.0) to 21 cM. Data obtained for the tissue plasminogen activator locus, located at 8p12, excluded linkage to 4 cM. These results exclude between 20 to 30% of chromosome 8 as a possible map location for the NF gene in this family. Comparison of the two DNA markers excluded their linkage to 0.5 cM.

Original languageEnglish (US)
Pages (from-to)532-534
Number of pages3
JournalJournal of medical genetics
Volume24
Issue number9
DOIs
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Fingerprint Dive into the research topics of 'Linkage analysis of peripheral neurofibromatosis to DNA markers on chromosome 8'. Together they form a unique fingerprint.

Cite this