Linkage analysis of candidate myelin genes in familial multiple sclerosis

Eric Seboun, Jorge R. Oksenberg, Antony Rombos, Koishiro Usuku, Donald E. Goodkin, Robin R. Lincoln, Michael Wong, D. Pham-Dinh, O. Boesplug-Tanguy, R. Carsique, R. Fitoussi, C. Gartioux, C. Reyes, F. Ribierre, S. Faure, C. Fizames, G. Gyapay, J. Weissenbach, A. Dautigny, Jackie B. Rimmler & 4 others Melissa E. Garcia, Margaret A Pericak-Vance, Jonathan L. Haines, Stephen L. Hauser

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system. A complex genetic etiology is thought to underlie susceptibility to this disease. The present study was designed to analyze whether differences in genes that encode myelin proteins influence susceptibility to MS. We performed linkage analysis of MS to markers in chromosomal regions that include the genes encoding myelin basic protein (MBP), proteolipid protein (PLP), myelin-associated glycoprotein (MAG), oligodendrocyte myelin glycoprotein (OMGP), and myelin oligodendrocyte glycoprotein (MOG) in a well-characterized population of 65 multiplex MS families consisting of 399 total individuals, 169 affected with MS and 102 affected sibpairs. Physical mapping data permitted placement of MAG and PLP genes on the Genethon genetic map; all other genes were mapped on the Genethon genetic map by linkage analysis. For each gene, at least one marker within the gene and/or two tightly linked flanking markers were analyzed. Marker data analysis employed a combination of genetic trait model-dependent (parametric) and model-independent linkage methods. Results indicate that MAG, MBP, OMGP, and PLP genes do not have a significant genetic effect on susceptibility to MS in this population. As MOG resides within the MHC, a potential role of the MOG gene could not be excluded.

Original languageEnglish
Pages (from-to)155-162
Number of pages8
JournalNeurogenetics
Volume2
Issue number3
DOIs
StatePublished - Oct 26 1999
Externally publishedYes

Fingerprint

Genetic Association Studies
Myelin Sheath
Multiple Sclerosis
Myelin-Oligodendrocyte Glycoprotein
Myelin-Associated Glycoprotein
Oligodendrocyte-Myelin Glycoprotein
Genes
Proteolipids
Myelin Basic Protein
CNS Demyelinating Autoimmune Diseases
Myelin Proteolipid Protein
Myelin Proteins
Genetic Linkage
Genetic Models
Disease Susceptibility
Population
Proteins

Keywords

  • Genetics
  • Multiple sclerosis
  • Myelin basic protein
  • Myelin oligodendrocyte glycoprotein
  • Proteolipid protein

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuroscience(all)

Cite this

Seboun, E., Oksenberg, J. R., Rombos, A., Usuku, K., Goodkin, D. E., Lincoln, R. R., ... Hauser, S. L. (1999). Linkage analysis of candidate myelin genes in familial multiple sclerosis. Neurogenetics, 2(3), 155-162. https://doi.org/10.1007/s100480050076

Linkage analysis of candidate myelin genes in familial multiple sclerosis. / Seboun, Eric; Oksenberg, Jorge R.; Rombos, Antony; Usuku, Koishiro; Goodkin, Donald E.; Lincoln, Robin R.; Wong, Michael; Pham-Dinh, D.; Boesplug-Tanguy, O.; Carsique, R.; Fitoussi, R.; Gartioux, C.; Reyes, C.; Ribierre, F.; Faure, S.; Fizames, C.; Gyapay, G.; Weissenbach, J.; Dautigny, A.; Rimmler, Jackie B.; Garcia, Melissa E.; Pericak-Vance, Margaret A; Haines, Jonathan L.; Hauser, Stephen L.

In: Neurogenetics, Vol. 2, No. 3, 26.10.1999, p. 155-162.

Research output: Contribution to journalArticle

Seboun, E, Oksenberg, JR, Rombos, A, Usuku, K, Goodkin, DE, Lincoln, RR, Wong, M, Pham-Dinh, D, Boesplug-Tanguy, O, Carsique, R, Fitoussi, R, Gartioux, C, Reyes, C, Ribierre, F, Faure, S, Fizames, C, Gyapay, G, Weissenbach, J, Dautigny, A, Rimmler, JB, Garcia, ME, Pericak-Vance, MA, Haines, JL & Hauser, SL 1999, 'Linkage analysis of candidate myelin genes in familial multiple sclerosis', Neurogenetics, vol. 2, no. 3, pp. 155-162. https://doi.org/10.1007/s100480050076
Seboun E, Oksenberg JR, Rombos A, Usuku K, Goodkin DE, Lincoln RR et al. Linkage analysis of candidate myelin genes in familial multiple sclerosis. Neurogenetics. 1999 Oct 26;2(3):155-162. https://doi.org/10.1007/s100480050076
Seboun, Eric ; Oksenberg, Jorge R. ; Rombos, Antony ; Usuku, Koishiro ; Goodkin, Donald E. ; Lincoln, Robin R. ; Wong, Michael ; Pham-Dinh, D. ; Boesplug-Tanguy, O. ; Carsique, R. ; Fitoussi, R. ; Gartioux, C. ; Reyes, C. ; Ribierre, F. ; Faure, S. ; Fizames, C. ; Gyapay, G. ; Weissenbach, J. ; Dautigny, A. ; Rimmler, Jackie B. ; Garcia, Melissa E. ; Pericak-Vance, Margaret A ; Haines, Jonathan L. ; Hauser, Stephen L. / Linkage analysis of candidate myelin genes in familial multiple sclerosis. In: Neurogenetics. 1999 ; Vol. 2, No. 3. pp. 155-162.
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