Linkage analysis in von Recklinghausen neurofibromatosis (NF1) with DNA markers for chromosome 17

B. R. Seizinger, G. A. Rouleau, A. H. Lane, G. Farmer, L. J. Ozelius, J. L. Haines, D. M. Parry, B. R. Korf, Margaret A Pericak-Vance, A. G. Faryniarz, W. J. Hobbs, J. A. Iannazzi, J. C. Roy, A. Menon, J. L. Bader, M. A. Spence, M. V. Chao, J. J. Mulvihill, A. D. Roses, R. L. Martuza & 3 others X. O. Breakefield, P. M. Conneally, J. F. Gusella

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Abstract

The mutant gene causing von Recklinghausen neurofibromatosis (NF1) was recently shown to map to chromosome 17. We have used additional markers for chromosome 17 to narrow further the location of the gene defect. A preliminary multipoint linkage analysis suggests that the NF1 gene is located on the long arm of chromosome 17, flanked by D17Z1 and NGFR. Linkage analysis with the human oncogene homolog erbA1, which maps to this region, suggests that this cancer-related gene is not the primary cause of NF1.

Original languageEnglish
Pages (from-to)346-348
Number of pages3
JournalGenomics
Volume1
Issue number4
DOIs
StatePublished - Jan 1 1987
Externally publishedYes

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Chromosomes, Human, Pair 17
Neurofibromatoses
Genetic Markers
Genes
Neoplasm Genes
Oncogenes

ASJC Scopus subject areas

  • Genetics

Cite this

Seizinger, B. R., Rouleau, G. A., Lane, A. H., Farmer, G., Ozelius, L. J., Haines, J. L., ... Gusella, J. F. (1987). Linkage analysis in von Recklinghausen neurofibromatosis (NF1) with DNA markers for chromosome 17. Genomics, 1(4), 346-348. https://doi.org/10.1016/0888-7543(87)90035-8

Linkage analysis in von Recklinghausen neurofibromatosis (NF1) with DNA markers for chromosome 17. / Seizinger, B. R.; Rouleau, G. A.; Lane, A. H.; Farmer, G.; Ozelius, L. J.; Haines, J. L.; Parry, D. M.; Korf, B. R.; Pericak-Vance, Margaret A; Faryniarz, A. G.; Hobbs, W. J.; Iannazzi, J. A.; Roy, J. C.; Menon, A.; Bader, J. L.; Spence, M. A.; Chao, M. V.; Mulvihill, J. J.; Roses, A. D.; Martuza, R. L.; Breakefield, X. O.; Conneally, P. M.; Gusella, J. F.

In: Genomics, Vol. 1, No. 4, 01.01.1987, p. 346-348.

Research output: Contribution to journalArticle

Seizinger, BR, Rouleau, GA, Lane, AH, Farmer, G, Ozelius, LJ, Haines, JL, Parry, DM, Korf, BR, Pericak-Vance, MA, Faryniarz, AG, Hobbs, WJ, Iannazzi, JA, Roy, JC, Menon, A, Bader, JL, Spence, MA, Chao, MV, Mulvihill, JJ, Roses, AD, Martuza, RL, Breakefield, XO, Conneally, PM & Gusella, JF 1987, 'Linkage analysis in von Recklinghausen neurofibromatosis (NF1) with DNA markers for chromosome 17', Genomics, vol. 1, no. 4, pp. 346-348. https://doi.org/10.1016/0888-7543(87)90035-8
Seizinger BR, Rouleau GA, Lane AH, Farmer G, Ozelius LJ, Haines JL et al. Linkage analysis in von Recklinghausen neurofibromatosis (NF1) with DNA markers for chromosome 17. Genomics. 1987 Jan 1;1(4):346-348. https://doi.org/10.1016/0888-7543(87)90035-8
Seizinger, B. R. ; Rouleau, G. A. ; Lane, A. H. ; Farmer, G. ; Ozelius, L. J. ; Haines, J. L. ; Parry, D. M. ; Korf, B. R. ; Pericak-Vance, Margaret A ; Faryniarz, A. G. ; Hobbs, W. J. ; Iannazzi, J. A. ; Roy, J. C. ; Menon, A. ; Bader, J. L. ; Spence, M. A. ; Chao, M. V. ; Mulvihill, J. J. ; Roses, A. D. ; Martuza, R. L. ; Breakefield, X. O. ; Conneally, P. M. ; Gusella, J. F. / Linkage analysis in von Recklinghausen neurofibromatosis (NF1) with DNA markers for chromosome 17. In: Genomics. 1987 ; Vol. 1, No. 4. pp. 346-348.
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AU - Roses, A. D.

AU - Martuza, R. L.

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AU - Conneally, P. M.

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