Linkage analysis in von Recklinghausen neurofibromatosis (NF1) with DNA markers for chromosome 17

B. R. Seizinger, G. A. Rouleau, A. H. Lane, G. Farmer, L. J. Ozelius, J. L. Haines, D. M. Parry, B. R. Korf, M. A. Pericak-Vance, A. G. Faryniarz, W. J. Hobbs, J. A. Iannazzi, J. C. Roy, A. Menon, J. L. Bader, M. A. Spence, M. V. Chao, J. J. Mulvihill, A. D. Roses, R. L. MartuzaX. O. Breakefield, P. M. Conneally, J. F. Gusella

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

The mutant gene causing von Recklinghausen neurofibromatosis (NF1) was recently shown to map to chromosome 17. We have used additional markers for chromosome 17 to narrow further the location of the gene defect. A preliminary multipoint linkage analysis suggests that the NF1 gene is located on the long arm of chromosome 17, flanked by D17Z1 and NGFR. Linkage analysis with the human oncogene homolog erbA1, which maps to this region, suggests that this cancer-related gene is not the primary cause of NF1.

Original languageEnglish (US)
Pages (from-to)346-348
Number of pages3
JournalGenomics
Volume1
Issue number4
DOIs
StatePublished - Dec 1987
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

Fingerprint Dive into the research topics of 'Linkage analysis in von Recklinghausen neurofibromatosis (NF1) with DNA markers for chromosome 17'. Together they form a unique fingerprint.

  • Cite this

    Seizinger, B. R., Rouleau, G. A., Lane, A. H., Farmer, G., Ozelius, L. J., Haines, J. L., Parry, D. M., Korf, B. R., Pericak-Vance, M. A., Faryniarz, A. G., Hobbs, W. J., Iannazzi, J. A., Roy, J. C., Menon, A., Bader, J. L., Spence, M. A., Chao, M. V., Mulvihill, J. J., Roses, A. D., ... Gusella, J. F. (1987). Linkage analysis in von Recklinghausen neurofibromatosis (NF1) with DNA markers for chromosome 17. Genomics, 1(4), 346-348. https://doi.org/10.1016/0888-7543(87)90035-8