Linkage analyses of chromosome 18 markers do not identify a major susceptibility locus for bipolar affective disorder in the old order Amish

D. L. Pauls, J. Ott, S. M. Paul, C. R. Allen, C. S.J. Fann, J. P. Carulli, K. M. Falls, C. A. Bouthillier, T. C. Gravius, T. P. Keith, J. A. Egeland, E. I. Ginns

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Previously reported linkage of bipolar affective disorder to DNA markers in the pericentromeric region of chromosome 18 was reexamined in a larger homogeneous sample of Old Order Amish families. Four markers (D18S21, D18S53, D18S44, and D18S40) were examined in three kindreds containing 31 bipolar 1 (BP I) individuals. Although linkage findings were replicated in the one previously studied Amish pedigree containing four BP l individuals, linkage to this region was excluded in the larger sample. If a susceptibility locus for bipolar disorder is located in this region of chromosome 18, it is of minor significance in this population.

Original languageEnglish (US)
Pages (from-to)636-643
Number of pages8
JournalAmerican journal of human genetics
Volume57
Issue number3
StatePublished - 1995

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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