Lineage involvement and karyotype in a patient with myelodysplasia and blood basophilia

Wael El-Rifai, Tom Pettersson, Marcelo L. Larramendy, Sakari Knuutila

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Abstract:  We report a 63‐year‐old woman with myelodysplastic syndrome (MDS), refractory anaemia with ring sideroblasts (RARS), and blood basophilia with pathological forms. Karyotype analysis revealed a complex rearrangement: 46,XX,del(3) (p13p25),del(5) (q13q33),der(16)t(1;16) (p 13;q 12)/47,idem,add(20) (?p1l)/49,idem, + add(1) (q32),add(20) (?p11), + mar/46,XX. Karyotype, immunophenotype and in situ hybridization studies by the MAC (morphology antibody chromosomes) combination technique revealed the chromosomal abnormality in granulocytic/monocytic and erythrocytic metaphase cells. Also mature basophils and other granulocytes were involved with the abnormality. We suggest that our patient with the MDS has a stem cell disorder affecting all myeloid cell lineages and that basophilia constitutes a part of the malignant process.

Original languageEnglish (US)
Pages (from-to)288-292
Number of pages5
JournalEuropean Journal of Haematology
Volume53
Issue number5
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

Fingerprint

Myelodysplastic Syndromes
Karyotype
Refractory Anemia
Mars
Basophils
Cell Lineage
Myeloid Cells
Metaphase
Granulocytes
Chromosome Aberrations
In Situ Hybridization
Stem Cells
Chromosomes
Antibodies

Keywords

  • blood basophilia
  • chromosome study
  • lineage involvement
  • myelodysplastic syndrome

ASJC Scopus subject areas

  • Hematology

Cite this

Lineage involvement and karyotype in a patient with myelodysplasia and blood basophilia. / El-Rifai, Wael; Pettersson, Tom; Larramendy, Marcelo L.; Knuutila, Sakari.

In: European Journal of Haematology, Vol. 53, No. 5, 01.01.1994, p. 288-292.

Research output: Contribution to journalArticle

El-Rifai, Wael ; Pettersson, Tom ; Larramendy, Marcelo L. ; Knuutila, Sakari. / Lineage involvement and karyotype in a patient with myelodysplasia and blood basophilia. In: European Journal of Haematology. 1994 ; Vol. 53, No. 5. pp. 288-292.
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