Abstract
Abstract: We report a 63‐year‐old woman with myelodysplastic syndrome (MDS), refractory anaemia with ring sideroblasts (RARS), and blood basophilia with pathological forms. Karyotype analysis revealed a complex rearrangement: 46,XX,del(3) (p13p25),del(5) (q13q33),der(16)t(1;16) (p 13;q 12)/47,idem,add(20) (?p1l)/49,idem, + add(1) (q32),add(20) (?p11), + mar/46,XX. Karyotype, immunophenotype and in situ hybridization studies by the MAC (morphology antibody chromosomes) combination technique revealed the chromosomal abnormality in granulocytic/monocytic and erythrocytic metaphase cells. Also mature basophils and other granulocytes were involved with the abnormality. We suggest that our patient with the MDS has a stem cell disorder affecting all myeloid cell lineages and that basophilia constitutes a part of the malignant process.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 288-292 |
| Number of pages | 5 |
| Journal | European Journal of Haematology |
| Volume | 53 |
| Issue number | 5 |
| DOIs | |
| State | Published - Jan 1 1994 |
| Externally published | Yes |
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Keywords
- blood basophilia
- chromosome study
- lineage involvement
- myelodysplastic syndrome
ASJC Scopus subject areas
- Hematology
Cite this
Lineage involvement and karyotype in a patient with myelodysplasia and blood basophilia. / El-Rifai, Wael; Pettersson, Tom; Larramendy, Marcelo L.; Knuutila, Sakari.
In: European Journal of Haematology, Vol. 53, No. 5, 01.01.1994, p. 288-292.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lineage involvement and karyotype in a patient with myelodysplasia and blood basophilia
AU - El-Rifai, Wael
AU - Pettersson, Tom
AU - Larramendy, Marcelo L.
AU - Knuutila, Sakari
PY - 1994/1/1
Y1 - 1994/1/1
N2 - Abstract: We report a 63‐year‐old woman with myelodysplastic syndrome (MDS), refractory anaemia with ring sideroblasts (RARS), and blood basophilia with pathological forms. Karyotype analysis revealed a complex rearrangement: 46,XX,del(3) (p13p25),del(5) (q13q33),der(16)t(1;16) (p 13;q 12)/47,idem,add(20) (?p1l)/49,idem, + add(1) (q32),add(20) (?p11), + mar/46,XX. Karyotype, immunophenotype and in situ hybridization studies by the MAC (morphology antibody chromosomes) combination technique revealed the chromosomal abnormality in granulocytic/monocytic and erythrocytic metaphase cells. Also mature basophils and other granulocytes were involved with the abnormality. We suggest that our patient with the MDS has a stem cell disorder affecting all myeloid cell lineages and that basophilia constitutes a part of the malignant process.
AB - Abstract: We report a 63‐year‐old woman with myelodysplastic syndrome (MDS), refractory anaemia with ring sideroblasts (RARS), and blood basophilia with pathological forms. Karyotype analysis revealed a complex rearrangement: 46,XX,del(3) (p13p25),del(5) (q13q33),der(16)t(1;16) (p 13;q 12)/47,idem,add(20) (?p1l)/49,idem, + add(1) (q32),add(20) (?p11), + mar/46,XX. Karyotype, immunophenotype and in situ hybridization studies by the MAC (morphology antibody chromosomes) combination technique revealed the chromosomal abnormality in granulocytic/monocytic and erythrocytic metaphase cells. Also mature basophils and other granulocytes were involved with the abnormality. We suggest that our patient with the MDS has a stem cell disorder affecting all myeloid cell lineages and that basophilia constitutes a part of the malignant process.
KW - blood basophilia
KW - chromosome study
KW - lineage involvement
KW - myelodysplastic syndrome
UR - http://www.scopus.com/inward/record.url?scp=0028598235&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028598235&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0609.1994.tb01321.x
DO - 10.1111/j.1600-0609.1994.tb01321.x
M3 - Article
C2 - 7813709
AN - SCOPUS:0028598235
VL - 53
SP - 288
EP - 292
JO - European Journal of Haematology
JF - European Journal of Haematology
SN - 0902-4441
IS - 5
ER -