To the Editor: In the June 14 issue of the Journal Stumacher, Kovnat and McCabe report endotoxemia in 60 per cent of patients with gram-negative sepsis. They regard the test as having only limited usefulness for the diagnosis of gram-negative sepsis. They are also skeptical of the role of endotoxemia in gram-negative septic shock because of the disparity between their data on the frequency of endotoxemia and of septic shock. Their diagnosis of endotoxemia was based on the result of 1 or more determinations soon after hospitalization or after the onset of fever. Such data have only limited value, because.
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