Limulus Assay for Endotoxin

Jacob Fine, Leopoldo Raij, William R. Mccabe

Research output: Contribution to journalLetterpeer-review

1 Scopus citations


To the Editor: In the June 14 issue of the Journal Stumacher, Kovnat and McCabe report endotoxemia in 60 per cent of patients with gram-negative sepsis. They regard the test as having only limited usefulness for the diagnosis of gram-negative sepsis. They are also skeptical of the role of endotoxemia in gram-negative septic shock because of the disparity between their data on the frequency of endotoxemia and of septic shock. Their diagnosis of endotoxemia was based on the result of 1 or more determinations soon after hospitalization or after the onset of fever. Such data have only limited value, because.

Original languageEnglish (US)
Pages (from-to)484-485
Number of pages2
JournalNew England Journal of Medicine
Issue number9
StatePublished - Aug 30 1973
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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