Limitations of diazoxide reversal of vasospasm

Roberto C. Heros; Michael H. Lavyne

doi:10.1161/01.STR.7.2.118

Limitations of diazoxide reversal of vasospasm

Roberto C. Heros, Michael H. Lavyne

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Diazoxide failed to safely relieve cerebral vasospasm by intracisternal injections in dogs and by intracarotid injections in monkeys despite in vitro documentation of arterial relaxation with this agent. Administration of the drug frequently produced hypertension and, in the presence of vasospasm, was associated with a high mortality rate.

Original language	English (US)
Pages (from-to)	118-120
Number of pages	3
Journal	Stroke
Volume	7
Issue number	2
DOIs	https://doi.org/10.1161/01.STR.7.2.118
State	Published - 1976
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology
Cardiology and Cardiovascular Medicine
Advanced and Specialized Nursing

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title = "Limitations of diazoxide reversal of vasospasm",

abstract = "Diazoxide failed to safely relieve cerebral vasospasm by intracisternal injections in dogs and by intracarotid injections in monkeys despite in vitro documentation of arterial relaxation with this agent. Administration of the drug frequently produced hypertension and, in the presence of vasospasm, was associated with a high mortality rate.",

author = "Heros, {Roberto C.} and Lavyne, {Michael H.}",

year = "1976",

doi = "10.1161/01.STR.7.2.118",

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AB - Diazoxide failed to safely relieve cerebral vasospasm by intracisternal injections in dogs and by intracarotid injections in monkeys despite in vitro documentation of arterial relaxation with this agent. Administration of the drug frequently produced hypertension and, in the presence of vasospasm, was associated with a high mortality rate.

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