Brierley et al initially described 3 cases of subacute encephalitis, resembling limbic encephalitis. Two of these patients did not show any detectable neoplasm, and the authors concluded that this condition was not necessarily associated with malignancy. Subsequently, however there have been multiple case reports of limbic encephalitis associated with neoplasm, and the entity is now commonly considered a paraneoplastic syndrome. We describe a 59-year-old man who developed limbic encephalitis in association with a benign thymoma. This represents the 1st report of limbic encephalitis associated with a benign thymoma or other benign neoplasm. Despite complete removal of the thymoma, inexorably progressive neurologic deterioration resulted in death.
ASJC Scopus subject areas
- Clinical Neurology