Life stress and cervical squamous intraepithelial lesions in women with human papillomavirus and human immunodeficiency virus

Deidre Byrnes Pereira, Michael H. Antoni, Aimee Danielson, Trudi Simon, Jo Nell Efantis-Potter, Charles S. Carver, Ron E.F. Durán, Gail Ironson, Nancy Klimas, Mary J. O'Sullivan

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

Objective: Human immunodeficiency virus (HIV)-infected women are at risk for cervical intraepithelial neoplasia (CIN) and cancer due to impaired immunosurveillance over human papillomavirus (HPV) infection. Life stress has been implicated in immune decrements in HIV-infected individuals and therefore may contribute to CIN progression over time. The purpose of this study was to determine whether life stress was associated with progression and/or persistence of squamous intraepithelial lesions (SIL), the cytologic diagnosis conferred by Papanicolaou smear, after 1-year follow-up among women co-infected with HIV and HPV. Method: Thirty-two HIV-infected African-American and Caribbean-American women underwent a psychosocial interview, blood draw, colposcopy, and HPV cervical swab at study entry. Using medical chart review, we then abstracted SIL diagnoses at study entry and after 1-year follow-up. Results: Hierarchical logistic regression analysis revealed that higher life stress increased the odds of developing progressive/persistent SIL over 1 year by approximately seven-fold after covarying relevant biological and behavioral control variables. Conclusions: These findings suggest that life stress may constitute an independent risk factor for SIL progression and/or persistence in HIV-infected women. Stress management interventions may decrease risk for SIL progression/persistence in women living with HIV.

Original languageEnglish (US)
Pages (from-to)427-434
Number of pages8
JournalPsychosomatic medicine
Volume65
Issue number3
DOIs
StatePublished - May 1 2003

Keywords

  • HIV
  • Human papillomavirus (HPV)
  • Psychoneuroimmunology (PNI)
  • Squamous intraepithelial lesions (SIL)
  • Stress
  • Women

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Psychology(all)

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