Abstract
There have been few investigations of the link between changes in life-course socioeconomic position (SEP) and cognitive decline or incidence of dementia. The authors examined the impact of changes in life-course SEP on incidence of dementia and cognitive impairment but not dementia (CIND) over a decade of follow-up. Participants of Mexican origin (n = 1,789) were members of the Sacramento Area Latino Study on Aging cohort. Incidence of dementia/CIND was ascertained by using standard diagnostic criteria. SEP indicators at 3 life stages (childhood, adulthood, and midlife) were used to derive a measure of cumulative SEP (range, 0 to 8) and SEP mobility. Nearly 24% of the sample maintained a low SEP throughout life. Hazard ratios and 95% confidence intervals were computed from Cox proportional hazards regression models. In fully adjusted models, participants with a continuously high SEP had lower hazard ratios for dementia/CIND compared with those with a continuously low SEP at all 3 life stages (hazard ratio = 0.49, 95% confidence interval: 0.24, 0.98; P = 0.04). In age-adjusted models, participants experienced a 16% greater hazard of dementia/CIND with every 1-unit increase in cumulative SEP disadvantage across the life course (hazard ratio = 1.16, 95% confidence interval: 1.01, 1.33; P = 0.04). Early exposures to social disadvantage may increase the risk of late-life dementia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1148-1158 |
| Number of pages | 11 |
| Journal | American Journal of Epidemiology |
| Volume | 173 |
| Issue number | 10 |
| DOIs | |
| State | Published - May 15 2011 |
| Externally published | Yes |
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Keywords
- aged
- dementia
- longitudinal studies
- Mexican Americans
- social class
- socioeconomic factors
ASJC Scopus subject areas
- Epidemiology
Cite this
Life-course socioeconomic position and incidence of dementia and cognitive impairment without dementia in older Mexican Americans : Results from the Sacramento Area Latino Study on Aging. / Zeki Al Hazzouri, Adina; Haan, Mary N.; Kalbfleisch, John D.; Galea, Sandro; Lisabeth, Lynda D.; Aiello, Allison E.
In: American Journal of Epidemiology, Vol. 173, No. 10, 15.05.2011, p. 1148-1158.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Life-course socioeconomic position and incidence of dementia and cognitive impairment without dementia in older Mexican Americans
T2 - Results from the Sacramento Area Latino Study on Aging
AU - Zeki Al Hazzouri, Adina
AU - Haan, Mary N.
AU - Kalbfleisch, John D.
AU - Galea, Sandro
AU - Lisabeth, Lynda D.
AU - Aiello, Allison E.
PY - 2011/5/15
Y1 - 2011/5/15
N2 - There have been few investigations of the link between changes in life-course socioeconomic position (SEP) and cognitive decline or incidence of dementia. The authors examined the impact of changes in life-course SEP on incidence of dementia and cognitive impairment but not dementia (CIND) over a decade of follow-up. Participants of Mexican origin (n = 1,789) were members of the Sacramento Area Latino Study on Aging cohort. Incidence of dementia/CIND was ascertained by using standard diagnostic criteria. SEP indicators at 3 life stages (childhood, adulthood, and midlife) were used to derive a measure of cumulative SEP (range, 0 to 8) and SEP mobility. Nearly 24% of the sample maintained a low SEP throughout life. Hazard ratios and 95% confidence intervals were computed from Cox proportional hazards regression models. In fully adjusted models, participants with a continuously high SEP had lower hazard ratios for dementia/CIND compared with those with a continuously low SEP at all 3 life stages (hazard ratio = 0.49, 95% confidence interval: 0.24, 0.98; P = 0.04). In age-adjusted models, participants experienced a 16% greater hazard of dementia/CIND with every 1-unit increase in cumulative SEP disadvantage across the life course (hazard ratio = 1.16, 95% confidence interval: 1.01, 1.33; P = 0.04). Early exposures to social disadvantage may increase the risk of late-life dementia.
AB - There have been few investigations of the link between changes in life-course socioeconomic position (SEP) and cognitive decline or incidence of dementia. The authors examined the impact of changes in life-course SEP on incidence of dementia and cognitive impairment but not dementia (CIND) over a decade of follow-up. Participants of Mexican origin (n = 1,789) were members of the Sacramento Area Latino Study on Aging cohort. Incidence of dementia/CIND was ascertained by using standard diagnostic criteria. SEP indicators at 3 life stages (childhood, adulthood, and midlife) were used to derive a measure of cumulative SEP (range, 0 to 8) and SEP mobility. Nearly 24% of the sample maintained a low SEP throughout life. Hazard ratios and 95% confidence intervals were computed from Cox proportional hazards regression models. In fully adjusted models, participants with a continuously high SEP had lower hazard ratios for dementia/CIND compared with those with a continuously low SEP at all 3 life stages (hazard ratio = 0.49, 95% confidence interval: 0.24, 0.98; P = 0.04). In age-adjusted models, participants experienced a 16% greater hazard of dementia/CIND with every 1-unit increase in cumulative SEP disadvantage across the life course (hazard ratio = 1.16, 95% confidence interval: 1.01, 1.33; P = 0.04). Early exposures to social disadvantage may increase the risk of late-life dementia.
KW - aged
KW - dementia
KW - longitudinal studies
KW - Mexican Americans
KW - social class
KW - socioeconomic factors
UR - http://www.scopus.com/inward/record.url?scp=79955759260&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79955759260&partnerID=8YFLogxK
U2 - 10.1093/aje/kwq483
DO - 10.1093/aje/kwq483
M3 - Article
VL - 173
SP - 1148
EP - 1158
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
SN - 0002-9262
IS - 10
ER -