Lichen planus associated with neoplasia: A cell-mediated immune response to tumor antigens?

Thomas N. Helm, Charles Camisa, Aries Y. Liu, Rafael Valenzuela, Wilma F. Bergfeld

Research output: Contribution to journalArticle

42 Scopus citations


Background: Individual case reports have suggested an occasional association of lichen planus with internal malignancy. Objective: Our purpose was to describe five patients with a neoplastic disease in whom lichen planus developed. Methods: Serologic and immunopathologic studies were conducted. Results: No evidence of autoantibody production characteristic of paraneoplastic pemphigus was found, and antibodies reactive with basal cell keratinocytes were not detected. Conclusion: Lichen planus may be rarely induced by neoplasia. A cell-mediated immune reaction possibly causes this phenomenon.

Original languageEnglish (US)
Pages (from-to)219-224
Number of pages6
JournalJournal of the American Academy of Dermatology
Issue number2
StatePublished - Jan 1 1994


ASJC Scopus subject areas

  • Dermatology

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