Lichen Planopilaris and Frontal Fibrosing Alopecia as Model Epithelial Stem Cell Diseases

Matthew J. Harries, Francisco Jimenez, Ander Izeta, Jonathan Hardman, Sreejith Parameswara Panicker, Enrique Poblet, Ralf Paus

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Inflammation-associated, irreversible damage to epithelial stem cells (eSCs) of the hair follicle in their immunologically privileged niche lies at the heart of scarring alopecia, which causes permanent difficult-to-treat hair loss. We propose that the two most common and closely related forms, lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA), provide excellent model diseases for studying the biology and pathology of adult human eSCs in an easily accessible human mini-organ. Emphasising the critical roles for interferon (IFN)-γ and peroxisome proliferator-activated receptor (PPAR)-γ-mediated signalling in immune privilege (IP) collapse and epithelial–mesenchymal transition (EMT) of these eSCs respectively, we argue that these pathways deserve therapeutic targeting in the future management of LPP/FFA and other eSC diseases associated with IP collapse and EMT.

Original languageEnglish (US)
Pages (from-to)435-448
Number of pages14
JournalTrends in Molecular Medicine
Volume24
Issue number5
DOIs
StatePublished - May 1 2018
Externally publishedYes

Fingerprint

Lichens
Alopecia
Stem Cells
Epithelial Cells
Peroxisome Proliferator-Activated Receptors
Hair Follicle
Interferons
Cicatrix
Pathology
Inflammation
Therapeutics

Keywords

  • epithelial–mesenchymal transition
  • hair follicle
  • immune privilege
  • interferon-γ
  • peroxisome proliferator-activated receptor-γ
  • stem cells

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

Cite this

Lichen Planopilaris and Frontal Fibrosing Alopecia as Model Epithelial Stem Cell Diseases. / Harries, Matthew J.; Jimenez, Francisco; Izeta, Ander; Hardman, Jonathan; Panicker, Sreejith Parameswara; Poblet, Enrique; Paus, Ralf.

In: Trends in Molecular Medicine, Vol. 24, No. 5, 01.05.2018, p. 435-448.

Research output: Contribution to journalReview article

Harries, Matthew J. ; Jimenez, Francisco ; Izeta, Ander ; Hardman, Jonathan ; Panicker, Sreejith Parameswara ; Poblet, Enrique ; Paus, Ralf. / Lichen Planopilaris and Frontal Fibrosing Alopecia as Model Epithelial Stem Cell Diseases. In: Trends in Molecular Medicine. 2018 ; Vol. 24, No. 5. pp. 435-448.
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