LH-RH analogues: I. Their impact on reproductive medicine

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64 Scopus citations


In the 28 years that have passed since the elucidation of the structure of luteinzing hormone-releasing hormone (LH-RH), diverse clinical applications in the field of reproductive medicine and related fields have been established for agonists of LH-RH, based on inhibition of the pituitary-gonadal axis. Various clinical investigations with agonists of LH-RH in benign gynecologic disorders, polycystic ovary disease (PCOD), in vitro fertilization-embryo transfer (IVF-ET), benign prostatic hypertrophy (BPH), precocious puberty and contraception were reviewed. LH-RH antagonists inhibit LH, follicle-stimulating hormone (FSH), and sex steroid secretion immediately after their administration and thus achieve rapid therapeutic effects. LH-RH antagonists should find applications in the treatment of uterine leiomyomas, endometriosis, and in controlled ovarian stimulation-assisted reproductive techniques (COS-ART), which have been already established for the agonists. Modern LH-RH antagonists such as cetrorelix may prove superior to the agonists in COS-ART and also in the treatment of BPH, but additional studies in these and other areas are needed.

Original languageEnglish (US)
Pages (from-to)401-409
Number of pages9
JournalGynecological Endocrinology
Issue number6
StatePublished - 1999
Externally publishedYes


  • ART
  • Endometriosis
  • Fibromas
  • LH-RH agonists
  • LH-RH antagonists

ASJC Scopus subject areas

  • Endocrinology
  • Obstetrics and Gynecology


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