LH releasing hormone and its analogues: recent basic and clinical investigations

A. V. Schally, A. J. Kastin, D. H. Coy

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100 Scopus citations


Recent basic and clinical studies on LH-RH and its analogues have been reviewed. It is clear that in the 4 years since the synthetic hormone became available, much interesting basic research has been done with it, particularly in the field of immunology, immunohistology and on the interaction of sex steroids and LH-RH in regulating LH and FSH release. Extensive investigations in the field of the synthesis of LH-RH analogues have also occurred. Many veterinary and clinical data on LH-RH have been accumulated. Available evidence indicates that LH-RH should find some diagnostic application in clinical medicine, but it is not yet a complete diagnostic agent for differentiating between hypothalamic and pituitary causes of hypogonadism. Long acting, superactive analogues of LH-RH may be useful therapeutically, particularly for induction of ovulation in women, and for treatment of oligospermia in men, but suitable regimens have not been devised yet. Two approaches, immunological, based on antisera to LH-RH, and synthetic, based on competitive analogues of LH-RH, have been proven to be feasible for development of new classes of drugs which may be useful in birth control.

Original languageEnglish (US)
Pages (from-to)1-30
Number of pages30
JournalInternational Journal of Fertility
Issue number1
StatePublished - Jan 1 1976
Externally publishedYes

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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