LH releasing hormone and its analogues

recent basic and clinical investigations

Andrew V Schally, A. J. Kastin, D. H. Coy

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Recent basic and clinical studies on LH-RH and its analogues have been reviewed. It is clear that in the 4 years since the synthetic hormone became available, much interesting basic research has been done with it, particularly in the field of immunology, immunohistology and on the interaction of sex steroids and LH-RH in regulating LH and FSH release. Extensive investigations in the field of the synthesis of LH-RH analogues have also occurred. Many veterinary and clinical data on LH-RH have been accumulated. Available evidence indicates that LH-RH should find some diagnostic application in clinical medicine, but it is not yet a complete diagnostic agent for differentiating between hypothalamic and pituitary causes of hypogonadism. Long acting, superactive analogues of LH-RH may be useful therapeutically, particularly for induction of ovulation in women, and for treatment of oligospermia in men, but suitable regimens have not been devised yet. Two approaches, immunological, based on antisera to LH-RH, and synthetic, based on competitive analogues of LH-RH, have been proven to be feasible for development of new classes of drugs which may be useful in birth control.

Original languageEnglish
Pages (from-to)1-30
Number of pages30
JournalInternational Journal of Fertility
Volume21
Issue number1
StatePublished - Dec 1 1976
Externally publishedYes

Fingerprint

Gonadotropin-Releasing Hormone
Oligospermia
Hypogonadism
Ovulation Induction
Clinical Medicine
Allergy and Immunology
Contraception
Immune Sera
Steroids
Hormones
Research
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

LH releasing hormone and its analogues : recent basic and clinical investigations. / Schally, Andrew V; Kastin, A. J.; Coy, D. H.

In: International Journal of Fertility, Vol. 21, No. 1, 01.12.1976, p. 1-30.

Research output: Contribution to journalArticle

@article{47d472f7089e42ad986346f62c06e8ce,
title = "LH releasing hormone and its analogues: recent basic and clinical investigations",
abstract = "Recent basic and clinical studies on LH-RH and its analogues have been reviewed. It is clear that in the 4 years since the synthetic hormone became available, much interesting basic research has been done with it, particularly in the field of immunology, immunohistology and on the interaction of sex steroids and LH-RH in regulating LH and FSH release. Extensive investigations in the field of the synthesis of LH-RH analogues have also occurred. Many veterinary and clinical data on LH-RH have been accumulated. Available evidence indicates that LH-RH should find some diagnostic application in clinical medicine, but it is not yet a complete diagnostic agent for differentiating between hypothalamic and pituitary causes of hypogonadism. Long acting, superactive analogues of LH-RH may be useful therapeutically, particularly for induction of ovulation in women, and for treatment of oligospermia in men, but suitable regimens have not been devised yet. Two approaches, immunological, based on antisera to LH-RH, and synthetic, based on competitive analogues of LH-RH, have been proven to be feasible for development of new classes of drugs which may be useful in birth control.",
author = "Schally, {Andrew V} and Kastin, {A. J.} and Coy, {D. H.}",
year = "1976",
month = "12",
day = "1",
language = "English",
volume = "21",
pages = "1--30",
journal = "International Journal of Fertility",
issn = "0020-725X",
publisher = "MSP International",
number = "1",

}

TY - JOUR

T1 - LH releasing hormone and its analogues

T2 - recent basic and clinical investigations

AU - Schally, Andrew V

AU - Kastin, A. J.

AU - Coy, D. H.

PY - 1976/12/1

Y1 - 1976/12/1

N2 - Recent basic and clinical studies on LH-RH and its analogues have been reviewed. It is clear that in the 4 years since the synthetic hormone became available, much interesting basic research has been done with it, particularly in the field of immunology, immunohistology and on the interaction of sex steroids and LH-RH in regulating LH and FSH release. Extensive investigations in the field of the synthesis of LH-RH analogues have also occurred. Many veterinary and clinical data on LH-RH have been accumulated. Available evidence indicates that LH-RH should find some diagnostic application in clinical medicine, but it is not yet a complete diagnostic agent for differentiating between hypothalamic and pituitary causes of hypogonadism. Long acting, superactive analogues of LH-RH may be useful therapeutically, particularly for induction of ovulation in women, and for treatment of oligospermia in men, but suitable regimens have not been devised yet. Two approaches, immunological, based on antisera to LH-RH, and synthetic, based on competitive analogues of LH-RH, have been proven to be feasible for development of new classes of drugs which may be useful in birth control.

AB - Recent basic and clinical studies on LH-RH and its analogues have been reviewed. It is clear that in the 4 years since the synthetic hormone became available, much interesting basic research has been done with it, particularly in the field of immunology, immunohistology and on the interaction of sex steroids and LH-RH in regulating LH and FSH release. Extensive investigations in the field of the synthesis of LH-RH analogues have also occurred. Many veterinary and clinical data on LH-RH have been accumulated. Available evidence indicates that LH-RH should find some diagnostic application in clinical medicine, but it is not yet a complete diagnostic agent for differentiating between hypothalamic and pituitary causes of hypogonadism. Long acting, superactive analogues of LH-RH may be useful therapeutically, particularly for induction of ovulation in women, and for treatment of oligospermia in men, but suitable regimens have not been devised yet. Two approaches, immunological, based on antisera to LH-RH, and synthetic, based on competitive analogues of LH-RH, have been proven to be feasible for development of new classes of drugs which may be useful in birth control.

UR - http://www.scopus.com/inward/record.url?scp=0017157980&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017157980&partnerID=8YFLogxK

M3 - Article

VL - 21

SP - 1

EP - 30

JO - International Journal of Fertility

JF - International Journal of Fertility

SN - 0020-725X

IS - 1

ER -