LH-releasing activity of potent LH-RH analogs in vitro

D. H. Coy, F. Labrie M. Savary, E. J. Coy, A. V. Schally

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


The LH-releasing activity of eight superactive analogs of LH-RH was measured in pituitary cells in primary culture. Introduction of the C-terminal ethylamide modification into [D-Ala6]- and [D-Leu6]-LH-RH (two peptides already 3 times more active than LH-RH) increases their activities 10-fold. [D-Phe6]- and [D-Trp6]-LH-RH are 90 and 100 times more active than LH-RH, respectively. The ethylamide derivatives of these two compounds are however approximately six times less active than the parent peptides.

Original languageEnglish (US)
Pages (from-to)576-582
Number of pages7
JournalBiochemical and biophysical research communications
Issue number2
StatePublished - Nov 17 1975
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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