The LH-releasing activity of eight superactive analogs of LH-RH was measured in pituitary cells in primary culture. Introduction of the C-terminal ethylamide modification into [D-Ala6]- and [D-Leu6]-LH-RH (two peptides already 3 times more active than LH-RH) increases their activities 10-fold. [D-Phe6]- and [D-Trp6]-LH-RH are 90 and 100 times more active than LH-RH, respectively. The ethylamide derivatives of these two compounds are however approximately six times less active than the parent peptides.
|Original language||English (US)|
|Number of pages||7|
|Journal||Biochemical and biophysical research communications|
|State||Published - Nov 17 1975|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology