Abstract
Ten healthy adults participated in a randomized, crossover drug interaction study testing procainamide only, procainamide plus levofloxacin, and procainamide plus ciprofloxacin. During levofloxacin therapy, most procainamide and N-acetylprocainamide (NAPA) pharmacokinetic parameters, including decreased renal clearances and renal clearance/creatinine clearance ratios, changed (P < 0.05). During ciprofloxacin treatment, only procainamide and NAPA renal clearances decreased significantly.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1649-1651 |
| Number of pages | 3 |
| Journal | Antimicrobial agents and chemotherapy |
| Volume | 49 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 2005 |
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases
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Bauer, L. A., Black, D. J., Lill, J. S., Garrison, J., Raisys, V. A., & Hooton, T. M. (2005). Levofloxacin and ciprofloxacin decrease procainamide and N-acetylprocainamide renal clearances. Antimicrobial agents and chemotherapy, 49(4), 1649-1651. https://doi.org/10.1128/AAC.49.4.1649-1651.2005