TY - JOUR
T1 - Levofloxacin and ciprofloxacin decrease procainamide and N-acetylprocainamide renal clearances
AU - Bauer, Larry A.
AU - Black, Douglas J.
AU - Lill, Jennifer S.
AU - Garrison, Julie
AU - Raisys, Vidmantas A.
AU - Hooton, Thomas M.
PY - 2005/4
Y1 - 2005/4
N2 - Ten healthy adults participated in a randomized, crossover drug interaction study testing procainamide only, procainamide plus levofloxacin, and procainamide plus ciprofloxacin. During levofloxacin therapy, most procainamide and N-acetylprocainamide (NAPA) pharmacokinetic parameters, including decreased renal clearances and renal clearance/creatinine clearance ratios, changed (P < 0.05). During ciprofloxacin treatment, only procainamide and NAPA renal clearances decreased significantly.
AB - Ten healthy adults participated in a randomized, crossover drug interaction study testing procainamide only, procainamide plus levofloxacin, and procainamide plus ciprofloxacin. During levofloxacin therapy, most procainamide and N-acetylprocainamide (NAPA) pharmacokinetic parameters, including decreased renal clearances and renal clearance/creatinine clearance ratios, changed (P < 0.05). During ciprofloxacin treatment, only procainamide and NAPA renal clearances decreased significantly.
UR - http://www.scopus.com/inward/record.url?scp=16244408295&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=16244408295&partnerID=8YFLogxK
U2 - 10.1128/AAC.49.4.1649-1651.2005
DO - 10.1128/AAC.49.4.1649-1651.2005
M3 - Article
C2 - 15793163
AN - SCOPUS:16244408295
VL - 49
SP - 1649
EP - 1651
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 4
ER -