Levofloxacin and ciprofloxacin decrease procainamide and N-acetylprocainamide renal clearances

Larry A. Bauer, Douglas J. Black, Jennifer S. Lill, Julie Garrison, Vidmantas A. Raisys, Thomas M. Hooton

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Ten healthy adults participated in a randomized, crossover drug interaction study testing procainamide only, procainamide plus levofloxacin, and procainamide plus ciprofloxacin. During levofloxacin therapy, most procainamide and N-acetylprocainamide (NAPA) pharmacokinetic parameters, including decreased renal clearances and renal clearance/creatinine clearance ratios, changed (P < 0.05). During ciprofloxacin treatment, only procainamide and NAPA renal clearances decreased significantly.

Original languageEnglish (US)
Pages (from-to)1649-1651
Number of pages3
JournalAntimicrobial agents and chemotherapy
Issue number4
StatePublished - Apr 2005
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases


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