Levofloxacin and ciprofloxacin decrease procainamide and N-acetylprocainamide renal clearances

Larry A. Bauer, Douglas J. Black, Jennifer S. Lill, Julie Garrison, Vidmantas A. Raisys, Thomas Hooton

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Ten healthy adults participated in a randomized, crossover drug interaction study testing procainamide only, procainamide plus levofloxacin, and procainamide plus ciprofloxacin. During levofloxacin therapy, most procainamide and N-acetylprocainamide (NAPA) pharmacokinetic parameters, including decreased renal clearances and renal clearance/creatinine clearance ratios, changed (P < 0.05). During ciprofloxacin treatment, only procainamide and NAPA renal clearances decreased significantly.

Original languageEnglish
Pages (from-to)1649-1651
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume49
Issue number4
DOIs
StatePublished - Apr 1 2005
Externally publishedYes

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Acecainide
Procainamide
Levofloxacin
Ciprofloxacin
Kidney
Drug Interactions
Creatinine
Pharmacokinetics
Therapeutics

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Levofloxacin and ciprofloxacin decrease procainamide and N-acetylprocainamide renal clearances. / Bauer, Larry A.; Black, Douglas J.; Lill, Jennifer S.; Garrison, Julie; Raisys, Vidmantas A.; Hooton, Thomas.

In: Antimicrobial Agents and Chemotherapy, Vol. 49, No. 4, 01.04.2005, p. 1649-1651.

Research output: Contribution to journalArticle

Bauer, Larry A. ; Black, Douglas J. ; Lill, Jennifer S. ; Garrison, Julie ; Raisys, Vidmantas A. ; Hooton, Thomas. / Levofloxacin and ciprofloxacin decrease procainamide and N-acetylprocainamide renal clearances. In: Antimicrobial Agents and Chemotherapy. 2005 ; Vol. 49, No. 4. pp. 1649-1651.
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