Abstract
We report a patient with Down's syndrome (DS) who developed progressive parkinsonian symptomatology at the age of 43 years. His parkinsonism was responsive to levodopa/carbidopa, but he developed end of dose wearing off. We discuss basal ganglia and dopamine abnormalities in DS and suggest that DS may be associated with parkinsonism.
Original language | English (US) |
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Pages (from-to) | 247-248 |
Number of pages | 2 |
Journal | European Neurology |
Volume | 30 |
Issue number | 5 |
DOIs | |
State | Published - 1990 |
Keywords
- Down's syndrome
- Parkinson's disease
- Parkinsonism
- Trisomy 21
ASJC Scopus subject areas
- Clinical Neurology