Levodopa-responsive parkinsonism in a patient with down’s syndrome1

Carlos Singer; Juan Sanchez-Ramos; William J. Weiner

doi:10.1159/000117355

Levodopa-responsive parkinsonism in a patient with down’s syndrome¹

Carlos Singer, Juan Sanchez-Ramos, William J. Weiner

Neurology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

We report a patient with Down's syndrome (DS) who developed progressive parkinsonian symptomatology at the age of 43 years. His parkinsonism was responsive to levodopa/carbidopa, but he developed end of dose wearing off. We discuss basal ganglia and dopamine abnormalities in DS and suggest that DS may be associated with parkinsonism.

Original language	English (US)
Pages (from-to)	247-248
Number of pages	2
Journal	European Neurology
Volume	30
Issue number	5
DOIs	https://doi.org/10.1159/000117355
State	Published - 1990

Keywords

Down's syndrome
Parkinson's disease
Parkinsonism
Trisomy 21

ASJC Scopus subject areas

Clinical Neurology

Access to Document

10.1159/000117355

Cite this

@article{cb5072ba910347e98ae64103f6f76c9e,

title = "Levodopa-responsive parkinsonism in a patient with down{\textquoteright}s syndrome1",

abstract = "We report a patient with Down's syndrome (DS) who developed progressive parkinsonian symptomatology at the age of 43 years. His parkinsonism was responsive to levodopa/carbidopa, but he developed end of dose wearing off. We discuss basal ganglia and dopamine abnormalities in DS and suggest that DS may be associated with parkinsonism.",

keywords = "Down's syndrome, Parkinson's disease, Parkinsonism, Trisomy 21",

author = "Carlos Singer and Juan Sanchez-Ramos and Weiner, {William J.}",

year = "1990",

doi = "10.1159/000117355",

language = "English (US)",

volume = "30",

pages = "247--248",

journal = "European Neurology",

issn = "0014-3022",

publisher = "S. Karger AG",

number = "5",

}

TY - JOUR

T1 - Levodopa-responsive parkinsonism in a patient with down’s syndrome1

AU - Singer, Carlos

AU - Sanchez-Ramos, Juan

AU - Weiner, William J.

PY - 1990

Y1 - 1990

N2 - We report a patient with Down's syndrome (DS) who developed progressive parkinsonian symptomatology at the age of 43 years. His parkinsonism was responsive to levodopa/carbidopa, but he developed end of dose wearing off. We discuss basal ganglia and dopamine abnormalities in DS and suggest that DS may be associated with parkinsonism.

AB - We report a patient with Down's syndrome (DS) who developed progressive parkinsonian symptomatology at the age of 43 years. His parkinsonism was responsive to levodopa/carbidopa, but he developed end of dose wearing off. We discuss basal ganglia and dopamine abnormalities in DS and suggest that DS may be associated with parkinsonism.

KW - Down's syndrome

KW - Parkinson's disease

KW - Parkinsonism

KW - Trisomy 21

UR - http://www.scopus.com/inward/record.url?scp=0025148818&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025148818&partnerID=8YFLogxK

U2 - 10.1159/000117355

DO - 10.1159/000117355

M3 - Article

C2 - 2148520

AN - SCOPUS:0025148818

VL - 30

SP - 247

EP - 248

JO - European Neurology

JF - European Neurology

SN - 0014-3022

IS - 5

ER -