Levodopa-responsive parkinsonism in a patient with down’s syndrome1

Carlos Singer, Juan Sanchez-Ramos, William J. Weiner

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


We report a patient with Down's syndrome (DS) who developed progressive parkinsonian symptomatology at the age of 43 years. His parkinsonism was responsive to levodopa/carbidopa, but he developed end of dose wearing off. We discuss basal ganglia and dopamine abnormalities in DS and suggest that DS may be associated with parkinsonism.

Original languageEnglish (US)
Pages (from-to)247-248
Number of pages2
JournalEuropean Neurology
Issue number5
StatePublished - 1990


  • Down's syndrome
  • Parkinson's disease
  • Parkinsonism
  • Trisomy 21

ASJC Scopus subject areas

  • Clinical Neurology


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