Levels of recent thymic emigrant cells decrease in children undergoing partial thymectomy during cardiac surgery

Ashish B. Madhok, A. Chandrasekran, Vincent Parnell, Mysore Gandhi, Devyani Chowdhury, Savita Pahwa

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

The human thymus is required for establishment of a T-cell pool in fetal life, but postnatal thymectomy is not known to cause immunodeficiency. T-cell emigration from thymus (thymic recent emigrants [TRECs]) is a continuous thymic-dependent process. We studied TREC levels pre- and post-partial thymectomy in children undergoing cardiac surgery. TRECs were quantitated by real-time PCR in peripheral blood lymphocytes of 24 children (0 to 12 years). TREC values were 47916 ± 9271 pre-partial thymectomy and 33157 ± 8479 post-partial thymectomy in 11 paired patients (P = 0.014). Interval between pre- and post-partial thymectomy was 8.8 days ± 5.8 days. Another group of 8 children had 30384 ± 9748 TRECs 16 days to 6 years post-partial thymectomy. There was a significant drop in TREC values post-partial thymectomy in the immediate postoperative period compared to prethymectomy TREC levels. While decreased thymic output may persist, the long-term implications were not evaluated in this patient population.

Original languageEnglish (US)
Pages (from-to)563-565
Number of pages3
JournalClinical and Diagnostic Laboratory Immunology
Volume12
Issue number5
DOIs
StatePublished - May 2005

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Clinical Biochemistry
  • Microbiology (medical)

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