Leukocytospermia in spinal cord injured patients is not related to histological inflammatory changes in the prostate

Josh M. Randall, Deena H. Evans, Vincent G. Bird, Teodoro C. Aballa, Charles M Lynne, Nancy Brackett

Research output: Contribution to journalArticle

12 Scopus citations


Purpose: Patients with spinal cord injuries have abnormal seminal plasma, which contributes to impaired sperm motility and viability. A common finding in these patients is an elevated leukocyte count in semen. We examined the prostatic tissue of spinal cord injured patients vs young healthy controls to determine whether a pathological process related to the prostate gland is a possible source of leukocytospermia. Materials and Methods: Seven men with a mean age of 26.1 years with spinal cord injury and 4 controls with a mean age of 35.0 years underwent standard transrectal ultrasound guided prostate biopsy. Semen analyses were performed prior to biopsies. At least 3 biopsy cores were obtained from each prostate and all underwent routine hematoxylin and eosin staining. Results: No significant abnormalities were found in any prostate biopsy cores. Two spinal cord injured patients had minor evidence of prostatic inflammation in 1 core. No inflammation was seen in any control specimens. None of the specimens showed signs of malignancy. Conclusions: Prostate biopsies obtained in this study did not show any signs of a chronic or acute significant inflammatory process that could explain increased leukocytospermia seen in patients with spinal cord injury.

Original languageEnglish
Pages (from-to)897-900
Number of pages4
JournalJournal of Urology
Issue number3
StatePublished - Sep 1 2003



  • Leukocytes
  • Prostate
  • Prostatitis
  • Spermatozoa
  • Spinal cord injuries

ASJC Scopus subject areas

  • Urology

Cite this