Leukocyte count is associated with reduced endothelial reactivity

Mitchell S V Elkind, Robert R. Sciacca, Bernadette Boden-Albala, Maria Lucia C Tondella, Daniel R. Feikin, Barry S. Fields, Ralph L Sacco, Marco R. Di Tullio, Shunichi Homma

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Background: Leukocyte count has been associated with cardiovascular and cerebrovascular disease in several studies. We hypothesized that white blood cell count is associated with endothelial reactivity. Methods and results: Leukocyte count was measured in a sample of stroke-free community participants undergoing brachial artery testing for endothelial reactivity. Flow-mediated dilation (FMD) during reactive hyperemia was assessed in each subject using high-resolution B-mode ultrasound. Multivariate linear regression was used to calculate the effect of leukocyte count on endothelial reactivity after adjusting for potential confounding factors. Mean age of the 868 participants was 66.7 ± 8.8 years; 57% were women. Mean leukocyte count was (6.1 ± 1.8) × 109/L. Each unit increase in leukocyte count was associated with a mean 0.18% decrease in FMD (p = 0.01). After adjusting for other atherosclerosis risk factors, including age, sex, hypertension, diabetes, hyperlipidemia, and smoking, the relationship persisted (mean decrease in FMD per unit leukocyte count = 0.17%, p = 0.02). There was a linear decrease in FMD by quartile of leukocyte count (p = 0.0014). The effect of leukocyte count on FMD was greater for women, those under age 70, and non-diabetics. Conclusions: Relative elevations in leukocyte count are associated with a reduction in brachial artery endothelial reactivity. These findings are consistent with current hypotheses regarding the inflammatory or infectious etiology of risk of atherosclerosis and stroke, but also suggest interactions with demographic and other risk factors.

Original languageEnglish
Pages (from-to)329-338
Number of pages10
JournalAtherosclerosis
Volume181
Issue number2
DOIs
StatePublished - Aug 1 2005
Externally publishedYes

Fingerprint

Leukocyte Count
Dilatation
Brachial Artery
Atherosclerosis
Stroke
Cerebrovascular Disorders
Hyperemia
Hyperlipidemias
Linear Models
Cardiovascular Diseases
Smoking
Demography
Hypertension

Keywords

  • Atherosclerosis
  • Endothelial reactivity
  • Epidemiology
  • Risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Elkind, M. S. V., Sciacca, R. R., Boden-Albala, B., Tondella, M. L. C., Feikin, D. R., Fields, B. S., ... Homma, S. (2005). Leukocyte count is associated with reduced endothelial reactivity. Atherosclerosis, 181(2), 329-338. https://doi.org/10.1016/j.atherosclerosis.2005.01.013

Leukocyte count is associated with reduced endothelial reactivity. / Elkind, Mitchell S V; Sciacca, Robert R.; Boden-Albala, Bernadette; Tondella, Maria Lucia C; Feikin, Daniel R.; Fields, Barry S.; Sacco, Ralph L; Di Tullio, Marco R.; Homma, Shunichi.

In: Atherosclerosis, Vol. 181, No. 2, 01.08.2005, p. 329-338.

Research output: Contribution to journalArticle

Elkind, MSV, Sciacca, RR, Boden-Albala, B, Tondella, MLC, Feikin, DR, Fields, BS, Sacco, RL, Di Tullio, MR & Homma, S 2005, 'Leukocyte count is associated with reduced endothelial reactivity', Atherosclerosis, vol. 181, no. 2, pp. 329-338. https://doi.org/10.1016/j.atherosclerosis.2005.01.013
Elkind MSV, Sciacca RR, Boden-Albala B, Tondella MLC, Feikin DR, Fields BS et al. Leukocyte count is associated with reduced endothelial reactivity. Atherosclerosis. 2005 Aug 1;181(2):329-338. https://doi.org/10.1016/j.atherosclerosis.2005.01.013
Elkind, Mitchell S V ; Sciacca, Robert R. ; Boden-Albala, Bernadette ; Tondella, Maria Lucia C ; Feikin, Daniel R. ; Fields, Barry S. ; Sacco, Ralph L ; Di Tullio, Marco R. ; Homma, Shunichi. / Leukocyte count is associated with reduced endothelial reactivity. In: Atherosclerosis. 2005 ; Vol. 181, No. 2. pp. 329-338.
@article{5cbab160f71542cdb38f92e50036f302,
title = "Leukocyte count is associated with reduced endothelial reactivity",
abstract = "Background: Leukocyte count has been associated with cardiovascular and cerebrovascular disease in several studies. We hypothesized that white blood cell count is associated with endothelial reactivity. Methods and results: Leukocyte count was measured in a sample of stroke-free community participants undergoing brachial artery testing for endothelial reactivity. Flow-mediated dilation (FMD) during reactive hyperemia was assessed in each subject using high-resolution B-mode ultrasound. Multivariate linear regression was used to calculate the effect of leukocyte count on endothelial reactivity after adjusting for potential confounding factors. Mean age of the 868 participants was 66.7 ± 8.8 years; 57{\%} were women. Mean leukocyte count was (6.1 ± 1.8) × 109/L. Each unit increase in leukocyte count was associated with a mean 0.18{\%} decrease in FMD (p = 0.01). After adjusting for other atherosclerosis risk factors, including age, sex, hypertension, diabetes, hyperlipidemia, and smoking, the relationship persisted (mean decrease in FMD per unit leukocyte count = 0.17{\%}, p = 0.02). There was a linear decrease in FMD by quartile of leukocyte count (p = 0.0014). The effect of leukocyte count on FMD was greater for women, those under age 70, and non-diabetics. Conclusions: Relative elevations in leukocyte count are associated with a reduction in brachial artery endothelial reactivity. These findings are consistent with current hypotheses regarding the inflammatory or infectious etiology of risk of atherosclerosis and stroke, but also suggest interactions with demographic and other risk factors.",
keywords = "Atherosclerosis, Endothelial reactivity, Epidemiology, Risk factors",
author = "Elkind, {Mitchell S V} and Sciacca, {Robert R.} and Bernadette Boden-Albala and Tondella, {Maria Lucia C} and Feikin, {Daniel R.} and Fields, {Barry S.} and Sacco, {Ralph L} and {Di Tullio}, {Marco R.} and Shunichi Homma",
year = "2005",
month = "8",
day = "1",
doi = "10.1016/j.atherosclerosis.2005.01.013",
language = "English",
volume = "181",
pages = "329--338",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Leukocyte count is associated with reduced endothelial reactivity

AU - Elkind, Mitchell S V

AU - Sciacca, Robert R.

AU - Boden-Albala, Bernadette

AU - Tondella, Maria Lucia C

AU - Feikin, Daniel R.

AU - Fields, Barry S.

AU - Sacco, Ralph L

AU - Di Tullio, Marco R.

AU - Homma, Shunichi

PY - 2005/8/1

Y1 - 2005/8/1

N2 - Background: Leukocyte count has been associated with cardiovascular and cerebrovascular disease in several studies. We hypothesized that white blood cell count is associated with endothelial reactivity. Methods and results: Leukocyte count was measured in a sample of stroke-free community participants undergoing brachial artery testing for endothelial reactivity. Flow-mediated dilation (FMD) during reactive hyperemia was assessed in each subject using high-resolution B-mode ultrasound. Multivariate linear regression was used to calculate the effect of leukocyte count on endothelial reactivity after adjusting for potential confounding factors. Mean age of the 868 participants was 66.7 ± 8.8 years; 57% were women. Mean leukocyte count was (6.1 ± 1.8) × 109/L. Each unit increase in leukocyte count was associated with a mean 0.18% decrease in FMD (p = 0.01). After adjusting for other atherosclerosis risk factors, including age, sex, hypertension, diabetes, hyperlipidemia, and smoking, the relationship persisted (mean decrease in FMD per unit leukocyte count = 0.17%, p = 0.02). There was a linear decrease in FMD by quartile of leukocyte count (p = 0.0014). The effect of leukocyte count on FMD was greater for women, those under age 70, and non-diabetics. Conclusions: Relative elevations in leukocyte count are associated with a reduction in brachial artery endothelial reactivity. These findings are consistent with current hypotheses regarding the inflammatory or infectious etiology of risk of atherosclerosis and stroke, but also suggest interactions with demographic and other risk factors.

AB - Background: Leukocyte count has been associated with cardiovascular and cerebrovascular disease in several studies. We hypothesized that white blood cell count is associated with endothelial reactivity. Methods and results: Leukocyte count was measured in a sample of stroke-free community participants undergoing brachial artery testing for endothelial reactivity. Flow-mediated dilation (FMD) during reactive hyperemia was assessed in each subject using high-resolution B-mode ultrasound. Multivariate linear regression was used to calculate the effect of leukocyte count on endothelial reactivity after adjusting for potential confounding factors. Mean age of the 868 participants was 66.7 ± 8.8 years; 57% were women. Mean leukocyte count was (6.1 ± 1.8) × 109/L. Each unit increase in leukocyte count was associated with a mean 0.18% decrease in FMD (p = 0.01). After adjusting for other atherosclerosis risk factors, including age, sex, hypertension, diabetes, hyperlipidemia, and smoking, the relationship persisted (mean decrease in FMD per unit leukocyte count = 0.17%, p = 0.02). There was a linear decrease in FMD by quartile of leukocyte count (p = 0.0014). The effect of leukocyte count on FMD was greater for women, those under age 70, and non-diabetics. Conclusions: Relative elevations in leukocyte count are associated with a reduction in brachial artery endothelial reactivity. These findings are consistent with current hypotheses regarding the inflammatory or infectious etiology of risk of atherosclerosis and stroke, but also suggest interactions with demographic and other risk factors.

KW - Atherosclerosis

KW - Endothelial reactivity

KW - Epidemiology

KW - Risk factors

UR - http://www.scopus.com/inward/record.url?scp=22544462841&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=22544462841&partnerID=8YFLogxK

U2 - 10.1016/j.atherosclerosis.2005.01.013

DO - 10.1016/j.atherosclerosis.2005.01.013

M3 - Article

C2 - 16039287

AN - SCOPUS:22544462841

VL - 181

SP - 329

EP - 338

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

IS - 2

ER -