Investigators have suggested either a B-lymphocytic or a histiocytic origin for the malignant cell in Hodgkin's disease. The results of cytologic, cytochemical, and immunologic studies of two morphologically different neoplasms encountered sequentially in a patient with nodular sclerosing Hodgkin's disease are reported. These results could suggest either B-lymphocytic or histiocytic origin for cytologically malignant cells in different sites. However, these results probably reflect differential expression of properties possessed by all Reed-Sternberg cells. These differences may have been induced by therapy. Thus, monocytic leukemia arising in a post-therapeutic setting may represent an overgrowth of one component of a single neoplasm rather than a new malignancy.
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