Leukemia occurring in treated Hodgkin's disease: Two neoplasms or one?

K. Sheibani, R. R. Tubbs, R. A. Savage, R. Valenzuela, B. A. Sebek, J. S. Hewlett

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Abstract

Investigators have suggested either a B-lymphocytic or a histiocytic origin for the malignant cell in Hodgkin's disease. The results of cytologic, cytochemical, and immunologic studies of two morphologically different neoplasms encountered sequentially in a patient with nodular sclerosing Hodgkin's disease are reported. These results could suggest either B-lymphocytic or histiocytic origin for cytologically malignant cells in different sites. However, these results probably reflect differential expression of properties possessed by all Reed-Sternberg cells. These differences may have been induced by therapy. Thus, monocytic leukemia arising in a post-therapeutic setting may represent an overgrowth of one component of a single neoplasm rather than a new malignancy.

Original languageEnglish (US)
Pages (from-to)39-47
Number of pages9
JournalUnknown Journal
Volume46
Issue number2
DOIs
StatePublished - Jan 1 1979

ASJC Scopus subject areas

  • Medicine(all)

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    Sheibani, K., Tubbs, R. R., Savage, R. A., Valenzuela, R., Sebek, B. A., & Hewlett, J. S. (1979). Leukemia occurring in treated Hodgkin's disease: Two neoplasms or one? Unknown Journal, 46(2), 39-47. https://doi.org/10.3949/ccjm.46.2.39