Lessons from yeast for clathrin-mediated endocytosis

Douglas R. Boettner, Richard J. Chi, Sandra K. Lemmon

Research output: Contribution to journalReview articlepeer-review

83 Scopus citations


Clathrin-mediated endocytosis (CME) is the major pathway for internalization of membrane proteins from the cell surface. Half a century of studies have uncovered tremendous insights into how a clathrin-coated vesicle is formed. More recently, the advent of live-cell imaging has provided a dynamic view of this process. As CME is highly conserved from yeast to humans, budding yeast provides an evolutionary template for this process and has been a valuable system for dissecting the underlying molecular mechanisms. In this review we trace the formation of a clathrin-coated vesicle from initiation to uncoating, focusing on key findings from the yeast system.

Original languageEnglish (US)
Pages (from-to)2-10
Number of pages9
JournalNature Cell Biology
Issue number1
StatePublished - Jan 2012

ASJC Scopus subject areas

  • Cell Biology


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