Lessons from yeast for clathrin-mediated endocytosis

Douglas R. Boettner, Richard J. Chi, Sandra Lemmon

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Clathrin-mediated endocytosis (CME) is the major pathway for internalization of membrane proteins from the cell surface. Half a century of studies have uncovered tremendous insights into how a clathrin-coated vesicle is formed. More recently, the advent of live-cell imaging has provided a dynamic view of this process. As CME is highly conserved from yeast to humans, budding yeast provides an evolutionary template for this process and has been a valuable system for dissecting the underlying molecular mechanisms. In this review we trace the formation of a clathrin-coated vesicle from initiation to uncoating, focusing on key findings from the yeast system.

Original languageEnglish
Pages (from-to)2-10
Number of pages9
JournalNature Cell Biology
Volume14
Issue number1
DOIs
StatePublished - Jan 1 2012

Fingerprint

Clathrin-Coated Vesicles
Clathrin
Endocytosis
Membrane Proteins
Yeasts
Saccharomycetales

ASJC Scopus subject areas

  • Cell Biology

Cite this

Lessons from yeast for clathrin-mediated endocytosis. / Boettner, Douglas R.; Chi, Richard J.; Lemmon, Sandra.

In: Nature Cell Biology, Vol. 14, No. 1, 01.01.2012, p. 2-10.

Research output: Contribution to journalArticle

Boettner, Douglas R. ; Chi, Richard J. ; Lemmon, Sandra. / Lessons from yeast for clathrin-mediated endocytosis. In: Nature Cell Biology. 2012 ; Vol. 14, No. 1. pp. 2-10.
@article{9694b83069844033a0ac8c591c3d7235,
title = "Lessons from yeast for clathrin-mediated endocytosis",
abstract = "Clathrin-mediated endocytosis (CME) is the major pathway for internalization of membrane proteins from the cell surface. Half a century of studies have uncovered tremendous insights into how a clathrin-coated vesicle is formed. More recently, the advent of live-cell imaging has provided a dynamic view of this process. As CME is highly conserved from yeast to humans, budding yeast provides an evolutionary template for this process and has been a valuable system for dissecting the underlying molecular mechanisms. In this review we trace the formation of a clathrin-coated vesicle from initiation to uncoating, focusing on key findings from the yeast system.",
author = "Boettner, {Douglas R.} and Chi, {Richard J.} and Sandra Lemmon",
year = "2012",
month = "1",
day = "1",
doi = "10.1038/ncb2403",
language = "English",
volume = "14",
pages = "2--10",
journal = "Nature Cell Biology",
issn = "1465-7392",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Lessons from yeast for clathrin-mediated endocytosis

AU - Boettner, Douglas R.

AU - Chi, Richard J.

AU - Lemmon, Sandra

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Clathrin-mediated endocytosis (CME) is the major pathway for internalization of membrane proteins from the cell surface. Half a century of studies have uncovered tremendous insights into how a clathrin-coated vesicle is formed. More recently, the advent of live-cell imaging has provided a dynamic view of this process. As CME is highly conserved from yeast to humans, budding yeast provides an evolutionary template for this process and has been a valuable system for dissecting the underlying molecular mechanisms. In this review we trace the formation of a clathrin-coated vesicle from initiation to uncoating, focusing on key findings from the yeast system.

AB - Clathrin-mediated endocytosis (CME) is the major pathway for internalization of membrane proteins from the cell surface. Half a century of studies have uncovered tremendous insights into how a clathrin-coated vesicle is formed. More recently, the advent of live-cell imaging has provided a dynamic view of this process. As CME is highly conserved from yeast to humans, budding yeast provides an evolutionary template for this process and has been a valuable system for dissecting the underlying molecular mechanisms. In this review we trace the formation of a clathrin-coated vesicle from initiation to uncoating, focusing on key findings from the yeast system.

UR - http://www.scopus.com/inward/record.url?scp=84255195061&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84255195061&partnerID=8YFLogxK

U2 - 10.1038/ncb2403

DO - 10.1038/ncb2403

M3 - Article

C2 - 22193158

AN - SCOPUS:84255195061

VL - 14

SP - 2

EP - 10

JO - Nature Cell Biology

JF - Nature Cell Biology

SN - 1465-7392

IS - 1

ER -