Lessons from yeast for clathrin-mediated endocytosis

Douglas R. Boettner; Richard J. Chi; Sandra K. Lemmon

doi:10.1038/ncb2403

Lessons from yeast for clathrin-mediated endocytosis

Douglas R. Boettner, Richard J. Chi, Sandra K. Lemmon

Molecular and Cellular Pharmacology

Research output: Contribution to journal › Review article › peer-review

81 Scopus citations

Abstract

Clathrin-mediated endocytosis (CME) is the major pathway for internalization of membrane proteins from the cell surface. Half a century of studies have uncovered tremendous insights into how a clathrin-coated vesicle is formed. More recently, the advent of live-cell imaging has provided a dynamic view of this process. As CME is highly conserved from yeast to humans, budding yeast provides an evolutionary template for this process and has been a valuable system for dissecting the underlying molecular mechanisms. In this review we trace the formation of a clathrin-coated vesicle from initiation to uncoating, focusing on key findings from the yeast system.

Original language	English (US)
Pages (from-to)	2-10
Number of pages	9
Journal	Nature Cell Biology
Volume	14
Issue number	1
DOIs	https://doi.org/10.1038/ncb2403
State	Published - Jan 2012

ASJC Scopus subject areas

Cell Biology

Access to Document

10.1038/ncb2403

Fingerprint Dive into the research topics of 'Lessons from yeast for clathrin-mediated endocytosis'. Together they form a unique fingerprint.

Cite this

@article{9694b83069844033a0ac8c591c3d7235,

title = "Lessons from yeast for clathrin-mediated endocytosis",

abstract = "Clathrin-mediated endocytosis (CME) is the major pathway for internalization of membrane proteins from the cell surface. Half a century of studies have uncovered tremendous insights into how a clathrin-coated vesicle is formed. More recently, the advent of live-cell imaging has provided a dynamic view of this process. As CME is highly conserved from yeast to humans, budding yeast provides an evolutionary template for this process and has been a valuable system for dissecting the underlying molecular mechanisms. In this review we trace the formation of a clathrin-coated vesicle from initiation to uncoating, focusing on key findings from the yeast system.",

author = "Boettner, {Douglas R.} and Chi, {Richard J.} and Lemmon, {Sandra K.}",

note = "Funding Information: We would like to thank J. A. Cooper and B. J. Galletta for insightful discussions, and C. Fahrenholtz for critical comments on the manuscript. This work was supported by grants and fellowships from the National Institutes of Health: F32-GM084677 (DRB), T32-HL07188 (RJC), F32-GM087900 (RJC), and R01-GM055796 (SKL). Finally, we apologize to colleagues whose work we were unable to cite in this brief review.",

year = "2012",

month = jan,

doi = "10.1038/ncb2403",

language = "English (US)",

volume = "14",

pages = "2--10",

journal = "Nature Cell Biology",

issn = "1465-7392",

publisher = "Nature Publishing Group",

number = "1",

}

TY - JOUR

T1 - Lessons from yeast for clathrin-mediated endocytosis

AU - Boettner, Douglas R.

AU - Chi, Richard J.

AU - Lemmon, Sandra K.

N1 - Funding Information: We would like to thank J. A. Cooper and B. J. Galletta for insightful discussions, and C. Fahrenholtz for critical comments on the manuscript. This work was supported by grants and fellowships from the National Institutes of Health: F32-GM084677 (DRB), T32-HL07188 (RJC), F32-GM087900 (RJC), and R01-GM055796 (SKL). Finally, we apologize to colleagues whose work we were unable to cite in this brief review.

PY - 2012/1

Y1 - 2012/1

N2 - Clathrin-mediated endocytosis (CME) is the major pathway for internalization of membrane proteins from the cell surface. Half a century of studies have uncovered tremendous insights into how a clathrin-coated vesicle is formed. More recently, the advent of live-cell imaging has provided a dynamic view of this process. As CME is highly conserved from yeast to humans, budding yeast provides an evolutionary template for this process and has been a valuable system for dissecting the underlying molecular mechanisms. In this review we trace the formation of a clathrin-coated vesicle from initiation to uncoating, focusing on key findings from the yeast system.

AB - Clathrin-mediated endocytosis (CME) is the major pathway for internalization of membrane proteins from the cell surface. Half a century of studies have uncovered tremendous insights into how a clathrin-coated vesicle is formed. More recently, the advent of live-cell imaging has provided a dynamic view of this process. As CME is highly conserved from yeast to humans, budding yeast provides an evolutionary template for this process and has been a valuable system for dissecting the underlying molecular mechanisms. In this review we trace the formation of a clathrin-coated vesicle from initiation to uncoating, focusing on key findings from the yeast system.

UR - http://www.scopus.com/inward/record.url?scp=84255195061&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84255195061&partnerID=8YFLogxK

U2 - 10.1038/ncb2403

DO - 10.1038/ncb2403

M3 - Review article

C2 - 22193158

AN - SCOPUS:84255195061

VL - 14

SP - 2

EP - 10

JO - Nature Cell Biology

JF - Nature Cell Biology

SN - 1465-7392

IS - 1

ER -