Lessons from yeast for clathrin-mediated endocytosis

Douglas R. Boettner; Richard J. Chi; Sandra K. Lemmon

doi:10.1038/ncb2403

Lessons from yeast for clathrin-mediated endocytosis

Douglas R. Boettner, Richard J. Chi, Sandra K. Lemmon

Molecular and Cellular Pharmacology

Research output: Contribution to journal › Review article › peer-review

83 Scopus citations

Abstract

Clathrin-mediated endocytosis (CME) is the major pathway for internalization of membrane proteins from the cell surface. Half a century of studies have uncovered tremendous insights into how a clathrin-coated vesicle is formed. More recently, the advent of live-cell imaging has provided a dynamic view of this process. As CME is highly conserved from yeast to humans, budding yeast provides an evolutionary template for this process and has been a valuable system for dissecting the underlying molecular mechanisms. In this review we trace the formation of a clathrin-coated vesicle from initiation to uncoating, focusing on key findings from the yeast system.

Original language	English (US)
Pages (from-to)	2-10
Number of pages	9
Journal	Nature Cell Biology
Volume	14
Issue number	1
DOIs	https://doi.org/10.1038/ncb2403
State	Published - Jan 2012

ASJC Scopus subject areas

Cell Biology

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10.1038/ncb2403

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title = "Lessons from yeast for clathrin-mediated endocytosis",

abstract = "Clathrin-mediated endocytosis (CME) is the major pathway for internalization of membrane proteins from the cell surface. Half a century of studies have uncovered tremendous insights into how a clathrin-coated vesicle is formed. More recently, the advent of live-cell imaging has provided a dynamic view of this process. As CME is highly conserved from yeast to humans, budding yeast provides an evolutionary template for this process and has been a valuable system for dissecting the underlying molecular mechanisms. In this review we trace the formation of a clathrin-coated vesicle from initiation to uncoating, focusing on key findings from the yeast system.",

author = "Boettner, {Douglas R.} and Chi, {Richard J.} and Lemmon, {Sandra K.}",

note = "Funding Information: We would like to thank J. A. Cooper and B. J. Galletta for insightful discussions, and C. Fahrenholtz for critical comments on the manuscript. This work was supported by grants and fellowships from the National Institutes of Health: F32-GM084677 (DRB), T32-HL07188 (RJC), F32-GM087900 (RJC), and R01-GM055796 (SKL). Finally, we apologize to colleagues whose work we were unable to cite in this brief review.",

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Lessons from yeast for clathrin-mediated endocytosis

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