Abstract
Clathrin-mediated endocytosis (CME) is the major pathway for internalization of membrane proteins from the cell surface. Half a century of studies have uncovered tremendous insights into how a clathrin-coated vesicle is formed. More recently, the advent of live-cell imaging has provided a dynamic view of this process. As CME is highly conserved from yeast to humans, budding yeast provides an evolutionary template for this process and has been a valuable system for dissecting the underlying molecular mechanisms. In this review we trace the formation of a clathrin-coated vesicle from initiation to uncoating, focusing on key findings from the yeast system.
| Original language | English |
|---|---|
| Pages (from-to) | 2-10 |
| Number of pages | 9 |
| Journal | Nature Cell Biology |
| Volume | 14 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2012 |
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ASJC Scopus subject areas
- Cell Biology
Cite this
Lessons from yeast for clathrin-mediated endocytosis. / Boettner, Douglas R.; Chi, Richard J.; Lemmon, Sandra.
In: Nature Cell Biology, Vol. 14, No. 1, 01.01.2012, p. 2-10.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lessons from yeast for clathrin-mediated endocytosis
AU - Boettner, Douglas R.
AU - Chi, Richard J.
AU - Lemmon, Sandra
PY - 2012/1/1
Y1 - 2012/1/1
N2 - Clathrin-mediated endocytosis (CME) is the major pathway for internalization of membrane proteins from the cell surface. Half a century of studies have uncovered tremendous insights into how a clathrin-coated vesicle is formed. More recently, the advent of live-cell imaging has provided a dynamic view of this process. As CME is highly conserved from yeast to humans, budding yeast provides an evolutionary template for this process and has been a valuable system for dissecting the underlying molecular mechanisms. In this review we trace the formation of a clathrin-coated vesicle from initiation to uncoating, focusing on key findings from the yeast system.
AB - Clathrin-mediated endocytosis (CME) is the major pathway for internalization of membrane proteins from the cell surface. Half a century of studies have uncovered tremendous insights into how a clathrin-coated vesicle is formed. More recently, the advent of live-cell imaging has provided a dynamic view of this process. As CME is highly conserved from yeast to humans, budding yeast provides an evolutionary template for this process and has been a valuable system for dissecting the underlying molecular mechanisms. In this review we trace the formation of a clathrin-coated vesicle from initiation to uncoating, focusing on key findings from the yeast system.
UR - http://www.scopus.com/inward/record.url?scp=84255195061&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84255195061&partnerID=8YFLogxK
U2 - 10.1038/ncb2403
DO - 10.1038/ncb2403
M3 - Article
C2 - 22193158
AN - SCOPUS:84255195061
VL - 14
SP - 2
EP - 10
JO - Nature Cell Biology
JF - Nature Cell Biology
SN - 1465-7392
IS - 1
ER -