Lessons from yeast for clathrin-mediated endocytosis

Douglas R. Boettner; Richard J. Chi; Sandra K. Lemmon

doi:10.1038/ncb2403

Lessons from yeast for clathrin-mediated endocytosis

Douglas R. Boettner, Richard J. Chi, Sandra K. Lemmon

Molecular and Cellular Pharmacology

Research output: Contribution to journal › Review article

74 Scopus citations

Abstract

Clathrin-mediated endocytosis (CME) is the major pathway for internalization of membrane proteins from the cell surface. Half a century of studies have uncovered tremendous insights into how a clathrin-coated vesicle is formed. More recently, the advent of live-cell imaging has provided a dynamic view of this process. As CME is highly conserved from yeast to humans, budding yeast provides an evolutionary template for this process and has been a valuable system for dissecting the underlying molecular mechanisms. In this review we trace the formation of a clathrin-coated vesicle from initiation to uncoating, focusing on key findings from the yeast system.

Original language	English (US)
Pages (from-to)	2-10
Number of pages	9
Journal	Nature Cell Biology
Volume	14
Issue number	1
DOIs	https://doi.org/10.1038/ncb2403
State	Published - Jan 1 2012

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ASJC Scopus subject areas

Cell Biology

Cite this

Boettner, D. R., Chi, R. J., & Lemmon, S. K. (2012). Lessons from yeast for clathrin-mediated endocytosis. Nature Cell Biology, 14(1), 2-10. https://doi.org/10.1038/ncb2403

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10.1038/ncb2403