Abstract
Clathrin-mediated endocytosis (CME) is the major pathway for internalization of membrane proteins from the cell surface. Half a century of studies have uncovered tremendous insights into how a clathrin-coated vesicle is formed. More recently, the advent of live-cell imaging has provided a dynamic view of this process. As CME is highly conserved from yeast to humans, budding yeast provides an evolutionary template for this process and has been a valuable system for dissecting the underlying molecular mechanisms. In this review we trace the formation of a clathrin-coated vesicle from initiation to uncoating, focusing on key findings from the yeast system.
Original language | English (US) |
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Pages (from-to) | 2-10 |
Number of pages | 9 |
Journal | Nature Cell Biology |
Volume | 14 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2012 |
ASJC Scopus subject areas
- Cell Biology