Leptomeningeal failure of retinoblastoma

Amber Orman, Arnold Markoe, Peter A.S. Johnstone

Research output: Contribution to journalArticlepeer-review


Leptomeningeal (LM) failure of retinoblastoma (Rb) has not previously been reported. Upon review of our institutional experience of external beam radiotherapy (EBRT) for Rb, we found three LM failures. We sought to better define the clinical parameters of this type of recurrence. All children with LM failure had Reese-Ellsworth stage Vb eyes. Otherwise, no variables were significantly associated with LM failure. We theorize that this phenomenon is a function of the late-stage eyes for which EBRT is being reserved in the modern era.

Original languageEnglish (US)
Pages (from-to)533-535
Number of pages3
JournalPediatric Blood and Cancer
Issue number3
StatePublished - Mar 1 2015


  • Leptomeningeal disease
  • Pediatric malignancy
  • Retinoblastoma

ASJC Scopus subject areas

  • Oncology
  • Pediatrics, Perinatology, and Child Health
  • Hematology


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