Leptomeningeal failure of retinoblastoma

Amber Orman, Arnold Markoe, Peter A S Johnstone

Research output: Contribution to journalArticle

Abstract

Leptomeningeal (LM) failure of retinoblastoma (Rb) has not previously been reported. Upon review of our institutional experience of external beam radiotherapy (EBRT) for Rb, we found three LM failures. We sought to better define the clinical parameters of this type of recurrence. All children with LM failure had Reese-Ellsworth stage Vb eyes. Otherwise, no variables were significantly associated with LM failure. We theorize that this phenomenon is a function of the late-stage eyes for which EBRT is being reserved in the modern era.

Original languageEnglish
Pages (from-to)533-535
Number of pages3
JournalPediatric Blood and Cancer
Volume62
Issue number3
DOIs
StatePublished - Jan 1 2015

Fingerprint

Retinoblastoma
Radiotherapy
Recurrence

Keywords

  • Leptomeningeal disease
  • Pediatric malignancy
  • Retinoblastoma

ASJC Scopus subject areas

  • Oncology
  • Pediatrics, Perinatology, and Child Health
  • Hematology

Cite this

Leptomeningeal failure of retinoblastoma. / Orman, Amber; Markoe, Arnold; Johnstone, Peter A S.

In: Pediatric Blood and Cancer, Vol. 62, No. 3, 01.01.2015, p. 533-535.

Research output: Contribution to journalArticle

Orman, Amber ; Markoe, Arnold ; Johnstone, Peter A S. / Leptomeningeal failure of retinoblastoma. In: Pediatric Blood and Cancer. 2015 ; Vol. 62, No. 3. pp. 533-535.
@article{75f5f7fde2bd4bd5bfdd096f07ba54e8,
title = "Leptomeningeal failure of retinoblastoma",
abstract = "Leptomeningeal (LM) failure of retinoblastoma (Rb) has not previously been reported. Upon review of our institutional experience of external beam radiotherapy (EBRT) for Rb, we found three LM failures. We sought to better define the clinical parameters of this type of recurrence. All children with LM failure had Reese-Ellsworth stage Vb eyes. Otherwise, no variables were significantly associated with LM failure. We theorize that this phenomenon is a function of the late-stage eyes for which EBRT is being reserved in the modern era.",
keywords = "Leptomeningeal disease, Pediatric malignancy, Retinoblastoma",
author = "Amber Orman and Arnold Markoe and Johnstone, {Peter A S}",
year = "2015",
month = "1",
day = "1",
doi = "10.1002/pbc.25244",
language = "English",
volume = "62",
pages = "533--535",
journal = "Pediatric Blood and Cancer",
issn = "1545-5009",
publisher = "Wiley-Liss Inc.",
number = "3",

}

TY - JOUR

T1 - Leptomeningeal failure of retinoblastoma

AU - Orman, Amber

AU - Markoe, Arnold

AU - Johnstone, Peter A S

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Leptomeningeal (LM) failure of retinoblastoma (Rb) has not previously been reported. Upon review of our institutional experience of external beam radiotherapy (EBRT) for Rb, we found three LM failures. We sought to better define the clinical parameters of this type of recurrence. All children with LM failure had Reese-Ellsworth stage Vb eyes. Otherwise, no variables were significantly associated with LM failure. We theorize that this phenomenon is a function of the late-stage eyes for which EBRT is being reserved in the modern era.

AB - Leptomeningeal (LM) failure of retinoblastoma (Rb) has not previously been reported. Upon review of our institutional experience of external beam radiotherapy (EBRT) for Rb, we found three LM failures. We sought to better define the clinical parameters of this type of recurrence. All children with LM failure had Reese-Ellsworth stage Vb eyes. Otherwise, no variables were significantly associated with LM failure. We theorize that this phenomenon is a function of the late-stage eyes for which EBRT is being reserved in the modern era.

KW - Leptomeningeal disease

KW - Pediatric malignancy

KW - Retinoblastoma

UR - http://www.scopus.com/inward/record.url?scp=84921342588&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84921342588&partnerID=8YFLogxK

U2 - 10.1002/pbc.25244

DO - 10.1002/pbc.25244

M3 - Article

VL - 62

SP - 533

EP - 535

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

SN - 1545-5009

IS - 3

ER -