Abstract
Leptin, a peptide hormone released by adipose tissue, acts on the hypothalamus to control cravings and appetite. Leptin also acts to decrease taste responses to sweet substances, though there is little detailed information regarding where leptin acts in the taste transduction cascade. The present study examined the effects of leptin on sweet-evoked responses and neurotransmitter release from isolated taste buds. Our results indicate that leptin moderately decreased sweetevoked calcium mobilization in isolated mouse taste buds. We also employed Chinese hamster ovary biosensor cells to examine taste transmitter release from isolated taste buds. Leptin reduced ATP and increased serotonin release in response to sweet stimulation. However, leptin has no effect on bitter-evoked transmitter release, further showing that the action of leptin is sweet specific. Our results support those of previous studies, which state that leptin acts on taste tissue via the leptin receptor, most likely on Type II (Receptor) cells, but also possibly on Type III (Presynaptic) cells.
| Original language | English (US) |
|---|---|
| Article number | bju066 |
| Pages (from-to) | 217-222 |
| Number of pages | 6 |
| Journal | Chemical Senses |
| Volume | 40 |
| Issue number | 4 |
| DOIs | |
| State | Published - May 1 2015 |
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Keywords
- ATP
- Leptin
- Serotonin
- Taste bud
ASJC Scopus subject areas
- Sensory Systems
- Behavioral Neuroscience
- Physiology
- Physiology (medical)
Cite this
Leptin's effect on taste bud calcium responses and transmitter secretion. / Meredith, Tricia L.; Corcoran, Alan; Roper, Stephen D.
In: Chemical Senses, Vol. 40, No. 4, bju066, 01.05.2015, p. 217-222.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Leptin's effect on taste bud calcium responses and transmitter secretion
AU - Meredith, Tricia L.
AU - Corcoran, Alan
AU - Roper, Stephen D
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Leptin, a peptide hormone released by adipose tissue, acts on the hypothalamus to control cravings and appetite. Leptin also acts to decrease taste responses to sweet substances, though there is little detailed information regarding where leptin acts in the taste transduction cascade. The present study examined the effects of leptin on sweet-evoked responses and neurotransmitter release from isolated taste buds. Our results indicate that leptin moderately decreased sweetevoked calcium mobilization in isolated mouse taste buds. We also employed Chinese hamster ovary biosensor cells to examine taste transmitter release from isolated taste buds. Leptin reduced ATP and increased serotonin release in response to sweet stimulation. However, leptin has no effect on bitter-evoked transmitter release, further showing that the action of leptin is sweet specific. Our results support those of previous studies, which state that leptin acts on taste tissue via the leptin receptor, most likely on Type II (Receptor) cells, but also possibly on Type III (Presynaptic) cells.
AB - Leptin, a peptide hormone released by adipose tissue, acts on the hypothalamus to control cravings and appetite. Leptin also acts to decrease taste responses to sweet substances, though there is little detailed information regarding where leptin acts in the taste transduction cascade. The present study examined the effects of leptin on sweet-evoked responses and neurotransmitter release from isolated taste buds. Our results indicate that leptin moderately decreased sweetevoked calcium mobilization in isolated mouse taste buds. We also employed Chinese hamster ovary biosensor cells to examine taste transmitter release from isolated taste buds. Leptin reduced ATP and increased serotonin release in response to sweet stimulation. However, leptin has no effect on bitter-evoked transmitter release, further showing that the action of leptin is sweet specific. Our results support those of previous studies, which state that leptin acts on taste tissue via the leptin receptor, most likely on Type II (Receptor) cells, but also possibly on Type III (Presynaptic) cells.
KW - ATP
KW - Leptin
KW - Serotonin
KW - Taste bud
UR - http://www.scopus.com/inward/record.url?scp=84929413022&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84929413022&partnerID=8YFLogxK
U2 - 10.1093/chemse/bju066
DO - 10.1093/chemse/bju066
M3 - Article
C2 - 25537017
AN - SCOPUS:84929413022
VL - 40
SP - 217
EP - 222
JO - Chemical Senses
JF - Chemical Senses
SN - 0379-864X
IS - 4
M1 - bju066
ER -