Leptin's effect on taste bud calcium responses and transmitter secretion

Tricia L. Meredith, Alan Corcoran, Stephen D. Roper

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Leptin, a peptide hormone released by adipose tissue, acts on the hypothalamus to control cravings and appetite. Leptin also acts to decrease taste responses to sweet substances, though there is little detailed information regarding where leptin acts in the taste transduction cascade. The present study examined the effects of leptin on sweet-evoked responses and neurotransmitter release from isolated taste buds. Our results indicate that leptin moderately decreased sweetevoked calcium mobilization in isolated mouse taste buds. We also employed Chinese hamster ovary biosensor cells to examine taste transmitter release from isolated taste buds. Leptin reduced ATP and increased serotonin release in response to sweet stimulation. However, leptin has no effect on bitter-evoked transmitter release, further showing that the action of leptin is sweet specific. Our results support those of previous studies, which state that leptin acts on taste tissue via the leptin receptor, most likely on Type II (Receptor) cells, but also possibly on Type III (Presynaptic) cells.

Original languageEnglish (US)
Pages (from-to)217-222
Number of pages6
JournalChemical senses
Issue number4
StatePublished - May 1 2015


  • ATP
  • Leptin
  • Serotonin
  • Taste bud

ASJC Scopus subject areas

  • Physiology
  • Sensory Systems
  • Physiology (medical)
  • Behavioral Neuroscience


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